Nickel toxicity in the young bovine

Journal Article · Thu Jan 01 04:00:00 EST 1970 · J. Nutr.; (United States)

OSTI ID:5603198

O'Dell, G D; Miller, W J; King, W A; Moore, S L; Blackmon, D M

Twenty-three male dairy calves were fed (a) 0, (b) 62.5, (c) 250, or (d) 1000 ppm elemental nickel as NiCO/sub 3/ in the total diet from 13 to 21 weeks of age. Three animals on each treatment were subjected to digestion and balance trials and killed for tissue histological comparisons, and a like number (two for 62.5 ppm) were fed the basal ration in a 6-week posttreatment recovery period. Feed intake and growth rate were slightly retarded by 250 ppm Ni. Even though the calves fed 1000 ppm Ni had greatly reduced feed intake and lost weight during the 8-week treatment period, they were not emaciated and appeared to be younger than the others. During the posttreatment recovery period, growth rate of those which had been given 1000 ppm Ni was at least equal to that of the others. Digestibility coefficients were not affected by the Ni treatments but nitrogen retention was significantly lowered by 1000 ppm Ni and was associated with reduced feed intake. On a molar percentage basis, propionate was increased and butyrate decreased in rumen fluid from animals on the higher levels of nickel supplementation. Relative to body weight, the fresh weight of lung, heart, spleen, liver, gall bladder, kidney, brain, and testis was unaffected by treatments. Nickel did not affect ruminal, abomasal, duodenal, liver and testicular tissues histologically. Kidneys were nephritic, and the degree of severity increased with the nickel level. 26 references, 1 figure, 5 tables.

• Research Organization: Clemson Univ., SC
• OSTI ID: 5603198
• Journal Information: J. Nutr.; (United States), Journal Name: J. Nutr.; (United States) Vol. 100:12; ISSN JONUA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL GROWTH
ANIMALS
BIOLOGICAL RECOVERY
BODY
BRAIN
CARDIOVASCULAR SYSTEM
CATTLE
CENTRAL NERVOUS SYSTEM
DIET
DIGESTIVE SYSTEM
DOMESTIC ANIMALS
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
GLANDS
GONADS
GROWTH
HEART
KIDNEYS
LIVER
LUNGS
MALE GENITALS
MAMMALS
METABOLISM
METALS
NERVOUS SYSTEM
NICKEL
NITROGEN
NONMETALS
ORGANS
RECOVERY
RESPIRATORY SYSTEM
RUMINANTS
SPLEEN
TESTES
TOXICITY
TRANSITION ELEMENTS
VERTEBRATES
WEIGHT