High specific activity (samarium-153) EDTA for imaging of experimental tumor models

Journal Article · Wed Feb 01 04:00:00 EST 1989 · J. Nucl. Med.; (United States)

OSTI ID:5602070

Tse, J W; Wiebe, L I; Noujaim, A A

Enriched samarium oxide (98.2% /sup 152/Sm/sub 2/O/sub 3/) was irradiated in low neutron flux and high neutron flux reactors to produce /sup 153/Sm with specific activities of 14.3 GBq and 22.1 TBq mmol-1 Sm, respectively, at the time of use. Formulation of /sup 153/Sm as (/sup 153/Sm)EDTA, with a 1:10 molar ratio of SM:EDTA, provided a stable radiotracer in vitro and in vivo. High specific activity (/sup 153/Sm)EDTA showed superior uptake in cell culture (20.8 +/- 0.9% vs. 5.5 +/- 0.1% for 6 and 600 pmol Sm per 10(6) cells, respectively) and better tumor index values (51 vs. 37 at 10.9 nmol and 1.09 mumol Sm kg-1, respectively) in the BDF1 mouse/Lewis lung tumor model. High specific activity (153Sm)EDTA scintigrams of Copenhagen x Fisher rats bearing transplanted Dunning R3327 tumors clearly delineated the tumors within 6 hr, with moderate liver and bone uptake and low soft-tissue background. The injected radiotracer underwent rapid central compartment clearance and whole-body elimination. The absence of observed adverse histopathological toxicity combines with high image quality within 6 hr, to support the clinical tumor-imaging potential of this agent. Comparative studies with (/sup 67/Ga)citrate at molar-equivalent doses indicated that high specific activity (/sup 153/Sm)EDTA was a superior radiotracer in these in vitro and in vivo models.

• Research Organization: Univ. of Alberta, Edmonton (Canada)
• OSTI ID: 5602070
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 30:2; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
ANIMALS
BARYON REACTIONS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACID SALTS
CARBOXYLIC ACIDS
CHELATING AGENTS
CITRATES
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DISTRIBUTION
DRUGS
EDTA
ELECTRON CAPTURE RADIOISOTOPES
EVEN-EVEN NUCLEI
EVEN-ODD NUCLEI
EXPERIMENTAL NEOPLASMS
GALLIUM 67
GALLIUM ISOTOPES
HADRON REACTIONS
IN VITRO
INTERMEDIATE MASS NUCLEI
ISOTOPES
LABELLED COMPOUNDS
LUNGS
MAMMALS
MICE
NEOPLASMS
NEUTRON REACTIONS
NUCLEAR REACTIONS
NUCLEI
NUCLEON REACTIONS
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
RARE EARTH ISOTOPES
RARE EARTH NUCLEI
RATS
RESPIRATORY SYSTEM
RODENTS
SAMARIUM 152
SAMARIUM 153
SAMARIUM ISOTOPES
SCINTISCANNING
STABLE ISOTOPES
TISSUE DISTRIBUTION
UPTAKE
VERTEBRATES