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Title: Cyclotron Production of High–Specific Activity 55Co and In Vivo Evaluation of the Stability of 55Co Metal-Chelate-Peptide Complexes

Journal Article · · Molecular Imaging
 [1];  [1];  [1];  [1];  [1];  [1];  [1]
  1. Washington Univ., St. Louis, MO (United States)
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This work describes the production of high–specific activity 55Co and the evaluation of the stability of 55Co-metal-chelate-peptide complexes in vivo. 55Co was produced via the 58Ni(p,α)55Co reaction and purified using anion exchange chromatography with an average recovery of 92% and an average specific activity of 1.96 GBq/μmol. 55Co-DO3A and 55Co-NO2A peptide complexes were radiolabeled at 3.7 MBq/μg and injected into HCT-116 tumor xenografted mice. Positron emission tomography (PET) and biodistribution studies were performed at 24 and 48 hours postinjection and compared to those of 55CoCl2. Both 55Co-metal-chelate complexes demonstrated good in vivo stability by reducing the radiotracers’ uptake in the liver by sixfold at 24 hours with ˜ 1% ID/g and at 48 hours with ˜ 0.5% ID/g and reducing uptake in the heart by fourfold at 24 hours with ˜ 0.7% ID/g and sevenfold at 48 hours with ˜ 0.35% ID/g. Furthermore, these results support the use of 55Co as a promising new radiotracer for PET imaging of cancer and other diseases.

Research Organization:
Washington Univ., St. Louis, MO (United States)
Sponsoring Organization:
USDOE Office of Science (SC)
Grant/Contract Number:
SC0007352
OSTI ID:
1439276
Journal Information:
Molecular Imaging, Vol. 14, Issue 10; ISSN 1536-0121
Publisher:
SAGECopyright Statement
Country of Publication:
United States
Language:
English
Citation Metrics:
Cited by: 19 works
Citation information provided by
Web of Science

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Cited By (5)

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  • Aluicio-Sarduy, Eduardo; Ellison, Paul A.; Barnhart, Todd E.
  • Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 61, Issue 9 https://doi.org/10.1002/jlcr.3607
journal March 2018
Radiometals for imaging and theranostics, current production, and future perspectives
  • Mikolajczak, Renata; van der Meulen, Nicholas P.; Lapi, Suzanne E.
  • Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 62, Issue 10 https://doi.org/10.1002/jlcr.3770
journal July 2019
Physical properties, ligand substitution reactions, and biological activity of Co( iii )-Schiff base complexes journal January 2019
New 55Co-labeled Albumin-Binding Folate Derivatives as Potential PET Agents for Folate Receptor Imaging journal November 2019
New 55Co-labeled Albumin-Binding Folate Derivatives as Potential PET Agents for Folate Receptor Imaging text January 2019

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