Increased number of cardiac adrenergic receptors following local heart irradiation
- Institut fuer Strahlenbiologie, Neuherberg (Germany, F.R.)
The effect of local X irradiation on cardiac alpha and beta receptors was studied in Wistar rats. Animals were given local heart irradiation with single doses of 15 or 20 Gy and were examined after a range of latency times of 7 to 400 days. Using the radioactive ligands ({sup 3}H)CGP-12177 and ({sup 3}H)prazosin, the maximal binding capacity was determined from saturation experiments. At 7 days after 20 Gy the maximal binding capacity of both alpha and beta receptors was reduced to below the level of untreated control animals. Subsequently it rose continually to a maximum of 160% of the control level for beta receptors and 130% for alpha receptors at 400 days postirradiation. The antagonist affinity as judged from the dissociation constant for ({sup 3}H)CGP 12177 and ({sup 3}H)prazosin did not change significantly. A similar effect was observed after 15 Gy. An increase in adrenergic receptors may represent an important pathogenetic link between early morphological and late functional changes in the pathogenesis of radiation-induced heart disease.
- OSTI ID:
- 5600979
- Journal Information:
- Radiation Research; (USA), Journal Name: Radiation Research; (USA) Vol. 119:1; ISSN RAREA; ISSN 0033-7587
- Country of Publication:
- United States
- Language:
- English
Similar Records
Effect of X irradiation on cardiac. beta. -adrenergic receptors in the rabbit
Norepinephrine-induced alteration in the coupling of. cap alpha. /sub 1/-adrenergic receptor occupancy to calcium efflux in rabbit aortic smooth muscle cells
Adrenal medullary regulation of rat renal cortical adrenergic receptors
Journal Article
·
Fri Nov 30 23:00:00 EST 1984
· Radiat. Res.; (United States)
·
OSTI ID:5968686
Norepinephrine-induced alteration in the coupling of. cap alpha. /sub 1/-adrenergic receptor occupancy to calcium efflux in rabbit aortic smooth muscle cells
Journal Article
·
Fri Feb 28 23:00:00 EST 1986
· Proc. Natl. Acad. Sci. U.S.A.; (United States)
·
OSTI ID:5766756
Adrenal medullary regulation of rat renal cortical adrenergic receptors
Journal Article
·
Sat Oct 31 23:00:00 EST 1987
· American Journal of Physiology; (USA)
·
OSTI ID:7007375
Related Subjects
550901 -- Pathology-- Tracer Techniques
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
HEART
HYDROGEN COMPOUNDS
IONIZING RADIATIONS
ISOTOPE APPLICATIONS
KINETICS
MAMMALS
MEMBRANE PROTEINS
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
PROTEINS
RADIATION EFFECTS
RADIATIONS
RATS
REACTION KINETICS
RECEPTORS
RODENTS
SYMPATHOMIMETICS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES
X RADIATION
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
HEART
HYDROGEN COMPOUNDS
IONIZING RADIATIONS
ISOTOPE APPLICATIONS
KINETICS
MAMMALS
MEMBRANE PROTEINS
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
PROTEINS
RADIATION EFFECTS
RADIATIONS
RATS
REACTION KINETICS
RECEPTORS
RODENTS
SYMPATHOMIMETICS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES
X RADIATION