Effect of X irradiation on cardiac. beta. -adrenergic receptors in the rabbit

Journal Article · Sat Dec 01 04:00:00 EST 1984 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3576414· OSTI ID:5968686

Timmermans, R; Gerber, G B

Cardiac ..beta.. receptors in rabbits were studied at different times following lethal (5 Gy) or supralethal (10 Gy) whole-body X irradiation. Using the radioactive ligand (/sup 125/I)iodiocyanopindolol, it was found that the maximal binding capacity, as determined from the Scatchard plot, decreased after 10 Gy whole-body X irradiation, whereas the dissociation constant was only little affected. Three days after an exposure to 5 Gy, maximal binding capacity was reduced slightly and tended toward control values at Day 7. Local irradiation of the cardiac region with 10 Gy reduced cardiac ..beta.. receptors after 3 days. The latter observation suggests that about half the effect of radiation on cardiac ..beta.. receptors originates from a direct action of radiation on the heart tissue, the rest being due to abscopal systemic reactions.

• Research Organization: CEN/SCK, Mol, Belgium
• OSTI ID: 5968686
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 100:3; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARDIOVASCULAR SYSTEM
CELL CONSTITUENTS
CELL MEMBRANES
CONFIGURATION INTERACTION
DAYS LIVING RADIOISOTOPES
DRUGS
ELECTROMAGNETIC RADIATION
ELECTRON CAPTURE RADIOISOTOPES
EXTERNAL IRRADIATION
HALOGEN COMPOUNDS
HEART
INHIBITION
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE COMPOUNDS
IODINE ISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOTOPES
LETHAL IRRADIATION
MAMMALS
MEMBRANES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RABBITS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RECEPTORS
SUPRALETHAL IRRADIATION
SYMPATHOMIMETICS
VERTEBRATES
WHOLE-BODY IRRADIATION
X RADIATION