Molecular phylogeny of the hominoid primates as indicated by two-dimensional protein electrophoresis

Journal Article · Fri May 01 00:00:00 EDT 1987 · Proc. Natl. Acad. Sci. U.S.A.; (United States)

DOI:https://doi.org/10.1073/pnas.84.10.3307· OSTI ID:5600693

Goldman, D; Giri, P R; O'Brien, J O

A molecular phylogeny for the hominoid primates was constructed by using genetic distances from a survey of 383 radiolabeled fibroblast polypeptides resolved by two-dimensional electrophoresis (2DE). An internally consistent matrix of Nei genetic distances was generated on the basis of variants in electrophoretic position. The derived phylogenetic tree indicated a branching sequence, from oldest to most recent, of cercopithecoids (Macaca fascicularis), gibbon-siamang, orangutan, gorilla, and human-chimpanzee. A cladistic analysis of 240 electrophoretic characters that varied between ape species produced an identical tree. Genetic distance measures obtained by 2DE are largely consistent with those generated by other molecular procedures. In addition, the 2DE data set appears to resolve the human-chimpanzee-gorilla trichotomy in favor of a more recent association of chimpanzees and humans.

• Research Organization: National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD
• OSTI ID: 5600693
• Journal Information: Proc. Natl. Acad. Sci. U.S.A.; (United States), Journal Name: Proc. Natl. Acad. Sci. U.S.A.; (United States) Vol. 84:10; ISSN PNASA
• Country of Publication: United States
• Language: English

Related Subjects

550401* -- Genetics-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
BIOLOGICAL EVOLUTION
BIOLOGY
CONNECTIVE TISSUE CELLS
ELECTROPHORESIS
FIBROBLASTS
GENETICS
LABELLED COMPOUNDS
MAMMALS
MAN
MOLECULAR BIOLOGY
MONKEYS
ORGANIC COMPOUNDS
PEPTIDES
POLYPEPTIDES
PRIMATES
PROTEINS
SOMATIC CELLS
TWO-DIMENSIONAL ELECTROPHORESIS
VERTEBRATES