Characterization of interleukin-8 receptors in non-human primates
- Hospital Central de Asturias, Oviedo (Spain); and others
Interleukin-8 is a chemokine with a potent neutrophil chemoatractant activity. In humans, two different cDNAs encoding human IL8 receptors designated IL8RA and IL8RB have been cloned. IL8RA binds IL8, while IL8RB binds IL8 as well as other {alpha}-chemokines. Both human IL8Rs are encoded by two genes physically linked on chromosome 2. The IL8RA and IL8RB genes have open reading frames (ORF) lacking introns. By direct sequencing of the polymerase chain reaction products, we sequenced the IL8R genes of cell lines from four non-human primates: chimpanzee, gorilla, orangutan, and macaca. The IL8RB encodes an ORF in the four non-human primates, showing 95%-99% similarity to the human IL8RB sequence. The IL8RA homologue in gorilla and chimpanzee consisted of two ORF 98%-99% identical to the human sequence. The macaca and orangutan IL8RA homologues are pseudogenes: a 2 base pair insertion generated a sequence with several stop codons. In addition, we describe the physical linkage of these genes in the four non-human primates and discuss the evolutionary implications of these findings. 25 refs., 5 figs., 3 tabs.
- OSTI ID:
- 273487
- Journal Information:
- Immunogenetics, Journal Name: Immunogenetics Journal Issue: 5 Vol. 43; ISSN 0093-7711; ISSN IMNGBK
- Country of Publication:
- United States
- Language:
- English
Similar Records
The ZNF75 zinc finger gene subfamily: Isolation and mapping of the four members in humans and great apes
Molecular phylogeny of the hominoid primates as indicated by two-dimensional protein electrophoresis
Resolution of the African hominoid trichotomy by use of a mitochondrial gene sequence
Journal Article
·
Mon Jul 15 00:00:00 EDT 1996
· Genomics
·
OSTI ID:469037
Molecular phylogeny of the hominoid primates as indicated by two-dimensional protein electrophoresis
Journal Article
·
Fri May 01 00:00:00 EDT 1987
· Proc. Natl. Acad. Sci. U.S.A.; (United States)
·
OSTI ID:5600693
Resolution of the African hominoid trichotomy by use of a mitochondrial gene sequence
Journal Article
·
Thu Feb 14 23:00:00 EST 1991
· Proceedings of the National Academy of Sciences of the United States of America; (United States)
·
OSTI ID:6144375