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Bioavailability of vitamin B-6 from rat diets containing wheat bran or cellulose

Journal Article · · J. Nutr.; (United States)
OSTI ID:5600509
; ;
Bioavailability of vitamin B-6 (B-6) in the total diet was studied in male, weanling Sprague-Dawley rats fed fiber-free (FF) diets with 0.2 or 6.9 mg pyridoxine/kg diet (0-, 2- or 6.9-PYR), 20% wheat bran (WB) diets with 3.9- or 5.5-PYR or 7% cellulose (C) diets with 0- or 2-PYR for 28 d. Body weight gain (mean +/- SEM) with 0-PYR was 70 +/- 9.0 and 81.2 +/- 4.2 g for FF and C, respectively. All other groups gained 170-180 g. Urinary excretion of 4-pyridoxic acid (4-PA), a major B-6 metabolite, for FF groups was 1.31 +/- 0.22, 2.26 +/- 0.28 and 6.39 +/- 1.73 micrograms/24 h, at 0-, 2- and 6.9-PYR, respectively. Rats fed WB diets excreted 4.99 +/- 0.58 and 9.81 +/- 0.76 micrograms/24 h (3.9- and 5.5-PYR, respectively) and those fed C diets excreted 1.46 +/- 0.34 and 2.69 +/- 0.72 micrograms/24 h (0- and 2-PYR). There was increasing turnover and shorter biological half-life of (/sup 14/C)pyridoxine (1 mu Ci injected on d 1) with increasing dietary B-6. Growth, 4-PA and /sup 14/C turnover data indicated that WB contributed to B-6 intake of these rats. Cellulose acted as a simple dietary diluent and had no effect on indices of B-6 status. These data suggest that dietary fiber, as cellulose or the indigestible component of wheat bran, does not adversely affect the bioavailability of vitamin B-6.
Research Organization:
Western Regional Research Center, Albany, CA
OSTI ID:
5600509
Journal Information:
J. Nutr.; (United States), Journal Name: J. Nutr.; (United States) Vol. 118:1; ISSN JONUA
Country of Publication:
United States
Language:
English

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Related Subjects

550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
AZINES
BIOLOGICAL AVAILABILITY
BIOLOGICAL HALF-LIFE
BODY
CARBOHYDRATES
CARBON 14 COMPOUNDS
CELLULOSE
CEREALS
DIET
DIGESTIVE SYSTEM
GLANDS
GRASS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LIVER
MAMMALS
METABOLISM
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PLANTS
POLYSACCHARIDES
PYRIDINES
PYRIDOXINE
RATS
RODENTS
SACCHARIDES
TRACER TECHNIQUES
VERTEBRATES
VITAMIN B GROUP
VITAMINS
WHEAT