Disposition of N-(4,6-dimethyl-2-pyrimidinyl)benzene(U-/sup 14/C)sulfonamide in the rat
Rats given a single oral dose of N-(4,6-dimethyl-2-pyrimidinyl)benzene(U-/sup 14/C)sulfonamide (/sup 14/C-DAS) excreted 64.2% of the /sup 14/C in the urine and 22.4% in the feces within 96 hr. Compounds accounting for 86% of the /sup 14/C in the 0-24-hr urine were isolated by a variety of chromatographic techniques and identified by IR, NMR, and MS analysis. Approximately 4% of the /sup 14/C in the urine was the parent compound. The structures of /sup 14/C-metabolites in the urine indicated that /sup 14/C-DAS was metabolized by at least three pathways which included: 1) hydroxylation and glucuronic acid conjugation at the 4-position of the benzene ring; 2) hydroxylation, and sulfate ester and glucuronic acid conjugation at the 5-position on the heterocyclic ring; and 3) hydroxylation and glucuronic acid conjugation of one methyl group on the heterocyclic ring.
- Research Organization:
- Dept. of Agriculture, Fargo, ND
- OSTI ID:
- 5600356
- Journal Information:
- Drug Metab. Dispos.; (United States), Journal Name: Drug Metab. Dispos.; (United States) Vol. 15:5; ISSN DMDSA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
AMIDES
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIMICROBIAL AGENTS
BIOLOGICAL PATHWAYS
CARBON 14 COMPOUNDS
CHROMATOGRAPHY
DRUGS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAGNETIC RESONANCE
MAMMALS
MASS SPECTROSCOPY
METABOLISM
METABOLITES
NUCLEAR MAGNETIC RESONANCE
ORAL ADMINISTRATION
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RATS
RESONANCE
RODENTS
SEPARATION PROCESSES
SPECTROSCOPY
SULFONAMIDES
TRACER TECHNIQUES
VERTEBRATES