Fate of ( sup 14 C)arsanilic acid in pigs and chickens
- Dept. of Agriculture, Fargo, ND (United States)
Arsanilic acid uniformly labeled with {sup 14}C in the benzene ring was used to determine the metabolic fate of oral arsanilic acid in pigs and chickens. Arsanilic acid was well absorbed in both species, and urine was the predominant route of excretion. The bile was a minor (< 5% of the dose) route of excretion in pigs; however, biliary excretion was not measured in roosters. Arsanilic acid, N-acetylarsanilic acid, and (4-acetamidophenyl)dimethylarsine oxide were isolated from pig urine (17-39%, 15-29%, and < 5% of urinary {sup 14}C, respectively). Only 25% of the {sup 14}C in pig feces was extractable, and no metabolites could be isolated. Arsanilic acid was the only radioactive compound isolated from urine of colostomized roosters, and there was no suggestion of other metabolites from the isolation scheme employed. No attempt was made to isolate {sup 14}C compounds in feces from colostomized roosters or in excreta from normal roosters.
- OSTI ID:
- 5530946
- Journal Information:
- Journal of Agricultural and Food Chemistry; (United States), Journal Name: Journal of Agricultural and Food Chemistry; (United States) Vol. 39:1; ISSN JAFCA; ISSN 0021-8561
- Country of Publication:
- United States
- Language:
- English
Similar Records
Metabolism and disposition of the flame retardant plasticizer, tri-p-cresyl phosphate, in the rat
Fate and distribution of 3H-labeled T-2 mycotoxin in guinea pigs. Interim report
Related Subjects
60 APPLIED LIFE SCIENCES
ADDITIVES
AMINES
ANIMAL FEEDS
ANIMALS
ARSANILIC ACID
ARSENIC COMPOUNDS
ARSONIC ACIDS
BILE
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BIRDS
BODY FLUIDS
CARBON 14 COMPOUNDS
CARBON COMPOUNDS
CLEARANCE
DOMESTIC ANIMALS
EXCRETION
FOOD
FOWL
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MATERIALS
METABOLISM
METABOLITES
ORGANIC ACIDS
ORGANIC ARSENIC COMPOUNDS
ORGANIC COMPOUNDS
SWINE
TRACER TECHNIQUES
URINE
VERTEBRATES
WASTES