Disposition and metabolism of 2-bromo-4,6-dinitroaniline in the male F344 rat
The disposition of (/sup 14/C)-2-bromo-4,6-dinitroaniline (BDNA) was studied in male F344 rats following oral or intravenous (iv) administration. The gastrointestinal absorption of BDNA was nearly complete and was not affected by dose in the range (10-100 ..mu..mol/kg body weight) studied. Following either oral or iv administration, BDNA was rapidly distributed throughout the tissues and showed no marked affinity for any particular tissue. Clearance of (/sup 14/C)BDNA-derived radioactivity from various tissues was rapid and was best described by two-component decay curves. The whole-body half-life of BDNA was approximately 7 h. Within 72 h, clearance of (/sup 14/C)BDNA-derived radioactivity from the body was 98% complete. (/sup 14/C)BDNA was rapidly cleared by metabolism to 13 metabolites, which were excreted in urine (62%) and feces (33%). Most (66%) of the urinary radioactivity was excreted in the form of sulfate conjugates of two metabolites of BDNA; excretion of unmetabolized BDNA was minimal (less than 2%). Biliary excretion of (/sup 14/C)BDNA was significant; however, some of this BDNA-derived radioactivity underwent enterohepatic circulation and was subsequently excreted in urine. Results of this study indicate that, if metabolism is a detoxification process, the rapid metabolism and excretion of this compound should minimize the likelihood of chronic toxicity from repeated exposure to BDNA beyond that predicted by data from acute or short-term exposures.
- Research Organization:
- National Institute of Environmental Health Sciences, Research Triangle Park, NC
- OSTI ID:
- 5721044
- Journal Information:
- J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 17:1; ISSN JTEHD
- Country of Publication:
- United States
- Language:
- English
Similar Records
Disposition of o-benzyl-p-chlorophenol in male rats
Tissue distribution of the tobacco-specific carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and its metabolites in F344 rats
Related Subjects
59 BASIC BIOLOGICAL SCIENCES
AMINES
ANILINE
ANIMALS
AROMATICS
BIOLOGICAL HALF-LIFE
BROMINE COMPOUNDS
CARBON 14 COMPOUNDS
CLEARANCE
DETOXIFICATION
DISTRIBUTION
EXCRETION
HALOGEN COMPOUNDS
INJECTION
INTAKE
INTRAVENOUS INJECTION
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
METABOLISM
METABOLITES
NITRO COMPOUNDS
ORAL ADMINISTRATION
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RATS
RETENTION
RODENTS
TISSUE DISTRIBUTION
TRACER TECHNIQUES
VERTEBRATES