A comparison of the cerebral uptake and metabolism of labeled glucose and deoxyglucose in vivo in rats
Experimental evidence indicated that: 1) (/sup 14/C)deoxyglucose-6-phosphate (/sup 14/C-DG-6-P) in brain (and other rat tissues) did not increase with time after injection of /sup 14/C-DG, 2) /sup 14/C-DG-6-P in rat brain (and other tissues) did not correlate with glucose metabolism, 3) /sup 14/C-DG-6-P in rat brain (and other tissues) had a significant negative correlation with glucose-6-phosphatase activity. Further, arterio-venous studies in rats, in which the cerebral uptake and metabolism of labeled glucose were compared directly with those of labeled DG (and labeled fluorodeoxyglucose, FDG), employing double labeled techniques, showed that DG (and FDG) cannot be used to measure glucose uptake and/or metabolism.
- Research Organization:
- New York State Rockland Research Institute, Orangeburg
- OSTI ID:
- 5589914
- Journal Information:
- Neurochem. Res.; (United States), Vol. 8:5
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ANTIMETABOLITES
UPTAKE
GLUCOSE
METABOLISM
CARBON 14 COMPOUNDS
CEREBRUM
DOUBLE LABELLING
PHOSPHATASES
RATS
TRACER TECHNIQUES
ALDEHYDES
ANIMALS
BODY
BRAIN
CARBOHYDRATES
CENTRAL NERVOUS SYSTEM
DRUGS
ENZYMES
ESTERASES
HEXOSES
HYDROLASES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LABELLING
MAMMALS
MONOSACCHARIDES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
RODENTS
SACCHARIDES
VERTEBRATES
550501* - Metabolism- Tracer Techniques