Colestipol hydrochloride prophylaxis of diarrhea during pelvic radiotherapy
Thirty-three patients were randomized prior to pelvic radiotherapy to receive the bile acid-sequestering resin colestipol hydrochloride, 5 grams qid, during the entire time of their therapy or diphenoxylate hydrochloride and atropine sulfate 2.5-20 mg per day (control) if they experienced diarrhea. The colestipol patients also took diphenoxylate if they had diarrhea. The patients in the colestipol group often experienced nausea, vomiting, and abdominal cramps and 8 were forced to discontinue the drug. There was no difference in the weekly stool frequency between the colestipol and the control patients but the colestipol patients who took at least 50% of the prescribed dose required fewer diphenoxylate tablets than the controls. The data suggest that colestipol hydrochloride is not of value in preventing radiation-induced diarrhea because of the side effects associated with the drug, but the theory on which the use of bile acid-sequestering agents is based may be correct.
- Research Organization:
- Pennsylvania State Univ., Hershey, PA
- OSTI ID:
- 5585995
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 9:2; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
Similar Records
Bile acids in radiation-induced diarrhea
Absence of bile acid malabsorption as a late effect of pelvic irradiation
Related Subjects
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
DIARRHEA
DIGESTIVE SYSTEM
GASTROINTESTINAL TRACT
INTESTINES
ION EXCHANGE MATERIALS
MATERIALS
MEDICINE
NAUSEA
NUCLEAR MEDICINE
ORGANS
PATIENTS
PELVIS
RADIATION EFFECTS
RADIOINDUCTION
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOTHERAPY
SIDE EFFECTS
SYMPTOMS
THERAPY
VOMITING