Damage and repair of irradiated mammalian brain

Conference · Sat Jul 01 04:00:00 EDT 1989

OSTI ID:5585394

Frankel, K; Lo, E; Phillips, M; Fabrikant, J; Brennan, K; Valk, P; Poljak, A; Delapaz, R; Woodruff, K ^[1]

---

1. Lawrence Berkeley Lab., CA (USA)

We have demonstrated that focal charged particle irradiation of the rabbit brain can create well-defined lesions which are observable by nuclear magnetic resonance imaging (NMR) and positron emission tomography (PET) imaging techniques. These are similar, in terms of location and characteristic NMR and PET features, to those that occur in the brain of about 10% of clinical research human subjects, who have been treated for intracranial vascular malformations with stereotactic radiosurgery. These lesions have been described radiologically as vasogenic edema of the deep white matter,'' and the injury is of variable intensity and temporal duration, can recede or progress to serious neurologic sequelae, and persist for a considerable period of time, frequently 18 mon to 3 yr. 8 refs., 6 figs.

• Research Organization: Lawrence Berkeley Lab., CA (USA)
• Sponsoring Organization: DOE/ER
• DOE Contract Number: AC03-76SF00098
• OSTI ID: 5585394
• Report Number(s): LBL-27582; CONF-890124--5; ON: DE90000141
• Country of Publication: United States
• Language: English

Related Subjects

560151 -- Radiation Effects on Animals-- Man
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ANIMALS
ANTIMETABOLITES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGY
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BRAIN
CAT SCANNING
CENTRAL NERVOUS SYSTEM
CEREBRUM
CHARGED PARTICLES
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DRUGS
EDEMA
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
EXTERNAL IRRADIATION
FLUORODEOXYGLUCOSE
HELIUM IONS
HOURS LIVING RADIOISOTOPES
INJURIES
INTERMEDIATE MASS NUCLEI
IONS
IRRADIATION
ISOTOPES
MAMMALS
MATERIALS
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NMR IMAGING
NUCLEI
ODD-ODD NUCLEI
ORGANS
PATHOLOGICAL CHANGES
PATIENTS
POSITRON COMPUTED TOMOGRAPHY
RABBITS
RADIATION EFFECTS
RADIATION INJURIES
RADIOBIOLOGY
RADIOISOTOPES
RECOVERY
RUBIDIUM 82
RUBIDIUM ISOTOPES
SYMPTOMS
TOMOGRAPHY
VERTEBRATES