Focal heavy charged particle irradiation of the mammalian cortex: Temporal pattern of changes followed by magnetic resonance imaging and positron emission tomography
Conference
·
OSTI ID:5400870
- Lawrence Berkeley Lab., CA (USA)
Studies in progress examine the radiation response of the normal rabbit brain to accelerated focal charged particle (helium, 230 MeV/u) beams. We have demonstrated that we can produce well-defined focal lesions that are detectable on nuclear magnetic resonance (NMR) and positron emission tomography (PET) imaging procedures in the rabbit brain. These lesions appear to be similar to those observed in humans following stereotactic heavy charged particle radiosurgery. The rabbit does not deteriorate neurologically with the appearance of these deep white matter lesions thereby permitting the examination of the cerebrovascular and metabolic basis of delayed radiations injury in the brain in vivo. The following report describes radiation-induced alterations in the rabbit brain observed with NMR and PET in vivo and the corresponding histopathological correlations.
- Research Organization:
- Lawrence Berkeley Lab., CA (USA)
- Sponsoring Organization:
- DOE/ER
- DOE Contract Number:
- AC03-76SF00098
- OSTI ID:
- 5400870
- Report Number(s):
- LBL-27638; CONF-8905227--1; ON: DE90001140
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOMEDICAL RADIOGRAPHY
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DELAYED RADIATION EFFECTS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DOSE-RESPONSE RELATIONSHIPS
EMISSION COMPUTED TOMOGRAPHY
MAMMALS
MEDICINE
NERVOUS SYSTEM
NMR IMAGING
NUCLEAR MEDICINE
ORGANS
POSITRON COMPUTED TOMOGRAPHY
RABBITS
RADIATION DOSE DISTRIBUTIONS
RADIATION EFFECTS
RADIOINDUCTION
RADIOLOGY
TECHNOLOGY ASSESSMENT
TOMOGRAPHY
USES
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOMEDICAL RADIOGRAPHY
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DELAYED RADIATION EFFECTS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DOSE-RESPONSE RELATIONSHIPS
EMISSION COMPUTED TOMOGRAPHY
MAMMALS
MEDICINE
NERVOUS SYSTEM
NMR IMAGING
NUCLEAR MEDICINE
ORGANS
POSITRON COMPUTED TOMOGRAPHY
RABBITS
RADIATION DOSE DISTRIBUTIONS
RADIATION EFFECTS
RADIOINDUCTION
RADIOLOGY
TECHNOLOGY ASSESSMENT
TOMOGRAPHY
USES
VERTEBRATES