Heavy charged-particle induced lesions in rabbit cerebral cortex
Journal Article
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
Fourteen male rabbits received single doses of 20, 40, and 80 Gy of neon irradiation with an extended Bragg peak. They were sacrificed at 1 day, 1 week, and 6 months post-irradiation. The tissue changes which showed a significant time-dose relationship were leakage of carbon particles from blood vessels, focal arachnoiditis, hemorrhage, cystic necrosis, and a total histopathologic score using a point system of grading. The focal nature of the lesions was clearly demonstrated with 2 mm thick macrotome sections. The transition zone between damaged brain and microscopically normal appearing brain was less than 1 mm and the tissue damage induced was morphologically similar to that of other radiation modalities. These findings may have important therapeutic implications for patients. The sharply demarcated boundaries of heavy charged-particle induced lesions suggest these beams will be useful for obliterating tissue in areas where it is critical that a transition from undamaged to severely damaged tissue must occur over a short distance, such as in the central nervous system.
- Research Organization:
- Brookside Hospital, San Pablo, CA (USA)
- OSTI ID:
- 5350101
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 14:2; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BEAMS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGY
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CEREBRAL CORTEX
CEREBRUM
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
FLUIDS
GASES
ION BEAMS
MAMMALS
NEON
NERVOUS SYSTEM
NONMETALS
ORGANS
RABBITS
RADIATION EFFECTS
RADIOBIOLOGY
RARE GASES
TIME DEPENDENCE
TOXICITY
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BEAMS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGY
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CEREBRAL CORTEX
CEREBRUM
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
FLUIDS
GASES
ION BEAMS
MAMMALS
NEON
NERVOUS SYSTEM
NONMETALS
ORGANS
RABBITS
RADIATION EFFECTS
RADIOBIOLOGY
RARE GASES
TIME DEPENDENCE
TOXICITY
VERTEBRATES