Current trends in mapping human genes

Journal Article · Tue Jan 01 04:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (USA)

OSTI ID:5583381

Mckusick, V A ^[1]

---

1. Johns Hopkins Univ. School of Medicine, Baltimore, MD (USA)

The human is estimated to have at least 50,000 expressed genes (gene loci). Some information is available concerning about 5,000 of these gene loci and about 1,900 have been mapped, i.e., assigned to specific chromosomes (and in most instances particular chromosome regions). Progress has been achieved by a combination of physical mapping (e.g., study of somatic cell hybrids and chromosomal in situ hybridization) and genetic mapping (e.g., genetic linkage studies). New methods for both physical and genetic mapping are expanding the armamentarium. The usefulness of the mapping information is already evident; the spin-off from the Human Genome Project (HGP) begins immediately. the complete nucleotide sequence is the ultimate map of the human genome. Sequencing, although already under way for limited segments of the genome, will await further progress in gene mapping, and in particular creation of contig maps for each chromosome. Meanwhile the technology of sequencing and sequence information handling will be developed.

• OSTI ID: 5583381
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (USA), Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (USA) Vol. 5:1; ISSN FAJOE; ISSN 0892-6638
• Country of Publication: United States
• Language: English

Related Subjects

550200 -- Biochemistry
550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BIOLOGY
COORDINATED RESEARCH PROGRAMS
DISEASES
DNA HYBRIDIZATION
DNA SEQUENCING
ECONOMICS
GENES
GENETIC MAPPING
GENETICS
HEREDITARY DISEASES
HYBRIDIZATION
MAMMALS
MAN
MAPPING
MOLECULAR BIOLOGY
PRIMATES
RESEARCH PROGRAMS
STRUCTURAL CHEMICAL ANALYSIS
VERTEBRATES