Regional localization of human chromosome 15 loci

Journal Article · Sat Oct 01 04:00:00 EDT 1994 · Genomics

DOI:https://doi.org/10.1006/geno.1994.1550· OSTI ID:183698

Richard, I; Broux, O; Chiannilkulchai, N ^[1]

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1. Localization Department, Evry (France); and others

One hundred forty-nine chromosome 15 loci were mapped by PCR with respect to chromosome breakpoints in three somatic cell hybrids retaining total or part of chromosome 15 and to a 10-Mb YAC contig. This chromosome was subdivided into 5 regions, yielding an average resolution of more than 1 sequence tagged site per megabase. The mapped loci included 18 genes, 60 cDNA-derived sequence tagged sites, and 69 microsatellites. In addition, the amount of chromosomes 15 retained in line A15.1 has been defined. This work represents the first attempt at an integration of the human physical, expression, and genetic maps of chromosome 15. 45 refs., 2 figs., 3 tabs.

• OSTI ID: 183698
• Journal Information: Genomics, Journal Name: Genomics Journal Issue: 3 Vol. 23; ISSN 0888-7543; ISSN GNMCEP
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
BIOLOGICAL MARKERS
CHROMOSOME BREAKAGE
CONTIGS
DNA SEQUENCING
GENES
GENETIC MAPPING
HUMAN CHROMOSOME 15
HYBRIDIZATION
POLYMERASE CHAIN REACTION
PROBES
RESOLUTION
SIZE
SOMATIC CELLS
YEASTS