A high-resolution interval map of the q21 region of the human X chromosome
- ICRF Laboratories, Oxford (United Kingdom); and others
- Laboratoire de Genetique Humaine, Vandoeuvre-les-Nancy (France); and others
In a previous study, we have developed a panel of chromosomal rearrangements for the physical mapping of the q13-q21 region of the human X chromosome. Here, we report the physical localization of 36 additional polymorphic markers by polymerase chain reaction analysis. The high density of chromosomal breakpoints in Xq21 allows us to map 58 DNA loci in 22 intervals. As a result, this segment of the X chromosome is saturated with approximately three sequence tagged sites per megabase of DNA, which will facilitate the construction of a YAC contig of this region. 26 refs., 1 fig., 1 tab.
- OSTI ID:
- 273447
- Journal Information:
- Genomics, Journal Name: Genomics Journal Issue: 3 Vol. 27; ISSN GNMCEP; ISSN 0888-7543
- Country of Publication:
- United States
- Language:
- English
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