In vitro biologic toxicity of native and surface-modified silica and kaolin
Journal Article
·
· J. Toxicol. Environ. Health; (United States)
An in vitro study of the biologic responses of surface-modified and native silica and kaolin was made to provide comparative information on the suppression of cytotoxicity by pulmonary surfactant. The release of alveolar macrophage cytoplasmic enzyme, lactate dehydrogenase (LDH), and lysosomal enzymes ..beta..-N-acetylglucosaminidase (..beta..-NAG) and ..beta..-glucuronidase (..beta..-GLUC) and sheep blood-cell hemolysis were monitored as indicators of cell membrane damage and cytotoxicity. Surface modification of silica and kaolin with dipalmitoyl lecithin (DPL) resulted in complete abrogation of cytotoxicity of both minerals. These findings indicate that surface modification of minerals with different adsorption properties by pulmonary surfactant generally lessens their prompt adverse effects.
- Research Organization:
- National Institute for Occupational Safety and Health, Morgantown, WV
- OSTI ID:
- 5583217
- Journal Information:
- J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 16:3-4; ISSN JTEHD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CELL CONSTITUENTS
CELL MEMBRANES
CHALCOGENIDES
CLAYS
DOMESTIC ANIMALS
ENZYMES
GLUCURONIDASE
GLYCOSYL HYDROLASES
HYDROLASES
IN VITRO
KAOLIN
LUNGS
MAMMALS
MATERIALS
MEMBRANES
MINERALS
O-GLYCOSYL HYDROLASES
ORGANS
OXIDE MINERALS
OXIDES
OXIDOREDUCTASES
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
RESPIRATORY SYSTEM
RUMINANTS
SHEEP
SILICA
SILICON COMPOUNDS
SILICON OXIDES
SURFACTANTS
TOXICITY
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CELL CONSTITUENTS
CELL MEMBRANES
CHALCOGENIDES
CLAYS
DOMESTIC ANIMALS
ENZYMES
GLUCURONIDASE
GLYCOSYL HYDROLASES
HYDROLASES
IN VITRO
KAOLIN
LUNGS
MAMMALS
MATERIALS
MEMBRANES
MINERALS
O-GLYCOSYL HYDROLASES
ORGANS
OXIDE MINERALS
OXIDES
OXIDOREDUCTASES
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
RESPIRATORY SYSTEM
RUMINANTS
SHEEP
SILICA
SILICON COMPOUNDS
SILICON OXIDES
SURFACTANTS
TOXICITY
VERTEBRATES