Estrogen action in the mouse uterus: differential nuclear localization of estradiol in uterine cell types
Autoradiographic studies of labeled steroid uptake in mouse uterine tissue indicated that labeled estradiol was predominantly sequestered in the nuclei of stromal and glandular epithelial cells at 1 h. Luminal epithelial cells did not show appreciable nuclear accumulation of labeled estradiol until 7-8 h after hormone injection. Studies using non-target tissues and unlabeled steroids indicated that the nuclear uptake events were tissue and estrogen steroid specific. The temporal pattern of steroid hormone uptake in the uterus would suggest that an initial interaction in stromal and glandular epithelial cells may be required prior to nuclear stimulation in the luminal epithelial target cell.
- OSTI ID:
- 5578490
- Journal Information:
- Endocrinology; (United States), Journal Name: Endocrinology; (United States) Vol. 108:5; ISSN ENDOA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL TISSUES
ANIMALS
AUTORADIOGRAPHY
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL LOCALIZATION
BODY
CELL CONSTITUENTS
CELL NUCLEI
EPITHELIUM
ESTRADIOL
ESTRANES
ESTROGENS
FEMALE GENITALS
HORMONES
HYDROXY COMPOUNDS
KINETICS
LABELLED COMPOUNDS
MAMMALS
MICE
ORGANIC COMPOUNDS
ORGANS
REACTION KINETICS
RODENTS
STEROID HORMONES
STEROIDS
TISSUES
UPTAKE
UTERUS
VERTEBRATES