Role of progesterone and estrogen in the preparation of the uterus and induction of implantation in the mouse
The implantation of the embryo into the uterine wall and subsequent decidualization of the uterine endometrium requires ovarian progesterone and estrogen. Prerequisites for implantation include (1) the preparation of the uterus for embryo implantation and (2) increase stromal capillary permeability at the site of embryo attachment. During the first three days of pregnancy, epithelial cells undergo proliferation, death and differentiation, in response to preovaluatory estrogen. These events occur in stromal cells in response to progesterone on days 4 and 5. The mechanism by which the steroid hormones modulate their functions and how estrogen initiates implantation in a progesterone-primed (P{sub 4}) uterus in not clearly understood. The author shows that 24h of P{sub 4}-priming is adequate for induction of implantation in the mouse. In addition, following this initial exposure of the uterus to P{sub 4} a long lasting effect is induced i.e. 24h of priming is no longer required for the induction of implantation. The uterine cell proliferation and differentiation that occurs in response to steroid hormones could be through their modulation of the expression of proto-oncogenes and growth factors. Results show that the proto-oncogene, c-myc and the growth factor, EGF are expressed in a cell-type specific manner in the uterus and are regulated by P{sub 4} and estrogen in a spatial and temporal manner during early pregnancy. It is apparent that c-myc protein in epithelia is primarily regulated by estrogen, while in the stroma by P{sub 4}. {sup 3}H-thymidine incorporation in specific uterine cell-types correlated with expression of the c-myc protein. On the other hand, EGF is always localized to the epithelia and is primarily regulated by estrogen.
- Research Organization:
- Kansas Univ., Lawrence, KS (USA)
- OSTI ID:
- 5735834
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
AZINES
BIOLOGICAL FUNCTIONS
BODY
EMBRYOS
EPITHELIUM
ESTROGENS
FEMALE GENITALS
HETEROCYCLIC COMPOUNDS
HORMONES
HYDROGEN COMPOUNDS
IMPLANTS
ISOTOPE APPLICATIONS
KETONES
MAMMALS
MICE
NUCLEOSIDES
NUCLEOTIDES
ONTOGENESIS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PREGNANCY
PREGNANES
PROGESTERONE
PYRIMIDINES
RIBOSIDES
RODENTS
STEROID HORMONES
STEROIDS
THYMIDINE
TISSUES
TRACER TECHNIQUES
TRITIUM COMPOUNDS
UTERUS
VERTEBRATES