Lung transplantation in the rat. III. Functional studies in iso- and allografts

Journal Article · Mon Aug 01 04:00:00 EDT 1983 · J. Surg. Res.; (United States)

DOI:https://doi.org/10.1016/0022-4804(83)90137-3· OSTI ID:5578365

Marck, K W; Prop, J; Wildevuur, C R

Recently a microsurgical technique for orthotopic left lung transplantation in the rat was developed. The aim of this study was to investigate the influence of the operation itself and of an unmodified rejection reaction on the function of the transplanted rat lung. Orthotopic left lung transplantation was performed in 59 rats (34 isografts and 25 allografts). Isografts demonstrated a mean left lung perfusion of 23.1% in the first two postoperative weeks. Seven out of the 10 animals, subjected to a repeated scintigraphy 5-10 weeks later, had an increased graft perfusion, resulting in an almost normal mean left lung perfusion of 34.8%. At that time chest roentgenography revealed a good aeration of the grafts, that at autopsy had a normal aspect. Allografts showed an initial mean left lung perfusion (24.6%) similar to the isografts, which, however, declined sharply a few days later (4.3%). At that time chest roentgenography revealed totally opalescent grafts that at autopsy had the hepatized aspect characteristic of lung allograft rejection. These results of isogeneic and allogeneic lung transplantation in the rat were comparable with those of canine auto- and allotransplantation. For immunogenetic and economical reasons lung transplantation in the rat is a good alternative animal model in lung transplantation research.

• Research Organization: Department of Experimental Surgery, University Hospital, Groningen, The Netherlands
• OSTI ID: 5578365
• Journal Information: J. Surg. Res.; (United States), Journal Name: J. Surg. Res.; (United States) Vol. 35:2; ISSN JSGRA
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MODELS
BIOMEDICAL RADIOGRAPHY
BODY
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
GRAFT-HOST REACTION
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LUNGS
MAMMALS
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOLOGY
RATS
RESPIRATORY SYSTEM
RODENTS
SCINTISCANNING
SURGERY
TECHNETIUM 99
TECHNETIUM ISOTOPES
TRANSPLANTS
VERTEBRATES
YEARS LIVING RADIOISOTOPES