Metabolism of nickel-63 carbonyl

Journal Article · Mon Jan 01 04:00:00 EST 1968 · Toxicol. Appl. Pharmacol.; (United States)

DOI:https://doi.org/10.1016/0041-008X(68)90033-1· OSTI ID:5575491

Sunderman, F W; Selin, C E

Sprague-Dawley male rats (150 to 200 g) were admin. /sup 63/Ni-labeled nickel carbonyl (Ni(CO)/sub 4/, a catalyst in the petroleum, rubber and plastic industries) either iv (2.2 mg Ni/100 g) or by inhalation (0.20 mg NI /liter air x 15 min). During the first 12 hr after iv injection, an average of 23.2% of the dose was excreted in the urine as /sup 63/Ni; average excretion fell to 3.7% during the second 12 hr and the average total urinary excretion during 4 days after injection was 31.2%. The average total fecal excretion was 2.4%; average biliary excretion during the first 6 hr after injection was 0.2%. The lung was the major excretory organ for /sup 63/Ni: 38.4% of the dose was exhaled in the first 6 hr after injection, but no /sup 63/Ni was exhaled thereafter. The average body burden of /sup 63/Ni at 24 hr was 17.7% of the dose; most was located in muscle and fat, bone and connective tissue, viscera and blood, with 1.1% in the brain and spinal cord. At 1 hr, 51.9% of the blood /sup 63/Ni was present in plasma; at 6 hr, 91.6% was in the plasma and 80.5% of this was bound to the serum proteins. At 6 hr after injection, an average of 1.63% was found in the lung and 0.69% in the liver; at 24 hr the average content fell to 0.76% and 0.33%, respectively. The tissue distribution of /sup 63/Ni in rats sacrificed 24 hr after inhalation differed from that after iv injection, the proportion of /sup 63/Ni in the viscera was greatly increased and the musculoskeletal system and fat levels were proportionately decreased; brain and spinal cord levels were also significantly higher.

• Research Organization: Florida College, Univ. of Medicine, Gainesville
• OSTI ID: 5575491
• Journal Information: Toxicol. Appl. Pharmacol.; (United States), Journal Name: Toxicol. Appl. Pharmacol.; (United States) Vol. 12:2; ISSN TXAPA
• Country of Publication: United States
• Language: English

Related Subjects

02 PETROLEUM
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59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADIPOSE TISSUE
ANIMAL TISSUES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD
BODY
BODY BURDEN
BODY FLUIDS
BRAIN
CARBONYLS
CENTRAL NERVOUS SYSTEM
CLEARANCE
CONNECTIVE TISSUE
DIGESTIVE SYSTEM
DISTRIBUTION
ELASTOMERS
ELEMENTS
EVEN-ODD NUCLEI
EXCRETION
EXHALATION
FECES
HAZARDS
HEALTH HAZARDS
INDUSTRY
INTERMEDIATE MASS NUCLEI
ISOTOPES
LUNG CLEARANCE
MATERIALS
METABOLISM
METALS
MUSCLES
NERVOUS SYSTEM
NICKEL
NICKEL 63
NICKEL ISOTOPES
NUCLEI
ORGANIC COMPOUNDS
ORGANIC POLYMERS
ORGANS
PETROLEUM INDUSTRY
PLASTICS INDUSTRY
POLYMERS
RADIOISOTOPES
RUBBERS
SKELETON
SPINAL CORD
TISSUE DISTRIBUTION
TISSUES
TRANSITION ELEMENTS
URINE
WASTES
YEARS LIVING RADIOISOTOPES