Use of implanted minipumps to study the effects of chelating drugs on renal /sup 63/Ni clearance in rats

Journal Article · Sun Dec 31 23:00:00 EST 1978 · Toxicol. Appl. Pharmacol.; (United States)

DOI:https://doi.org/10.1016/0041-008X(79)90463-0· OSTI ID:6482737

Shen, S K; Williams, S; Onkelinx, C; Sunderman, Jr, F W

Continuous administration of /sup 63/NiCl/sub 2/ solution was performed in rats by ip implantation of osmotically driven minipumps. Renal /sup 63/Ni clearance averaged 6.4 ml/hr during the interval from 24 to 96 hr after initiation of the infusion. During the infusion, plasma /sup 63/Ni concentrations at 4:00 p.m. averaged 36% higher than those at 9:00 a.m., suggesting diurnal fluctuation of nickel metabolism in rats. Three chelating drugs were administered to groups of six rats by sc implantation of minipumps during simultaneous ip infusion of /sup 63/NiCl/sub 2/, in order to compare the effectiveness of the drugs in enhancing renal /sup 63/Ni excretion.

• Research Organization: Univ. of Connecticut, Farmington
• OSTI ID: 6482737
• Journal Information: Toxicol. Appl. Pharmacol.; (United States), Journal Name: Toxicol. Appl. Pharmacol.; (United States) Vol. 51; ISSN TXAPA
• Country of Publication: United States
• Language: English

Related Subjects

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
CARBAMATES
CARBONIC ACID DERIVATIVES
CARBOXYLIC ACID SALTS
CARBOXYLIC ACIDS
CHELATING AGENTS
CHLORIDES
CHLORINE COMPOUNDS
CLEARANCE
DAILY VARIATIONS
DEDTC
DRUGS
EVEN-ODD NUCLEI
EXCRETION
HALIDES
HALOGEN COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
METABOLISM
NICKEL 63
NICKEL CHLORIDES
NICKEL COMPOUNDS
NICKEL ISOTOPES
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PENICILLAMINE
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RATS
RENAL CLEARANCE
RODENTS
TETA
THIOLS
TRANSITION ELEMENT COMPOUNDS
VARIATIONS
VERTEBRATES
YEARS LIVING RADIOISOTOPES