T4NOMO glottic cancer: an analysis of dose-time volume factors

Journal Article · Sun Nov 01 04:00:00 EST 1981 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(81)90079-1· OSTI ID:5572731

Harwood, A R; Beale, F A; Cummings, B J; Keane, T J; Payne, D; Rider, W D

Fifty-six patients with Stage T4NOMO glottic cancer who were treated with radical radiotherapy with surgery for salvage, are analyzed in detail with respect to the influence of extent of tumor, irradiation dose, field size and age on the local control of this type of glottic cancer. Forty-two patients were classified as T4 on the basis of cartilage destruction, tracheal or base of tongue involvement; 14 patients were classified on the basis of hypopharyngeal involvement. Local control by irradiation was 67% at 5 years in the T4 cartilage group as compared to 19% at 5 years in the T4 pyriform group (P = 0.001). Local control was 82% in the patients who received a dose of greater than 1700 ret as compared to 42% in those who received a nominal standard dose (NSD) of less than 1700 ret (P = 0.02). Irradiation field size and age of the patient have no influence on the local control by irradiation. It is concluded that radical radiotherapy with surgery for salvage is a good method of treatment for T4 glottic cancer, particularly in those patients who do not have hypopharyngeal involvement and that a minimum dose of 1700 ret is necessary for adequate control of tumor.

• Research Organization: Princess Margaret Hospital, Toronto, Ontario, Canada
• OSTI ID: 5572731
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 7:11; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
BODY
DIGESTIVE SYSTEM
DISEASES
DOSES
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATIENTS
PHARYNX
RADIATION DOSES
RADIOLOGY
RADIOTHERAPY
RESPIRATORY SYSTEM
SURGERY
THERAPY
TIME DEPENDENCE