Results of radical radiotherapeutic treatment of carcinoma of the pyriform sinus: experience of the Institut Curie

Journal Article · Sun Aug 01 04:00:00 EDT 1982 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(82)90576-4· OSTI ID:6514333

Bataini, P ^[1]; Brugere, J; Bernier, J; Jaulerry, C H; Picot, C; Ghossein, N A

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1. Institut Curie, Paris, France

Four hundred and thirty-four consecutive male patients received radical megavoltage radiotherapy for a squamous cell carcinoma of the pyriform sinus between 1958 and 1974. Those who had lateral epilaryngeal cancers were excluded since these tumors have a better prognosis. Cytological examination confirmed that 79% of patients had T3 disease and 72% had clinically involved metastatic nodes. The overall absolute and determinate survival at three years was 26% and 47%, and at five years 19% and 41%, respectively. The fact that the determinate survival is significantly better than the absolute survival is an indication that a sizable number of patients died of causes other than their primary tumor. Over half developed locoregional failure and could not be salvaged by surgery. Local control for patients with early stage cancer (T1-T2) who received less than 6500 rad was only 36%; it was 65% for those who received higher doses. There was no significant improvement with increasing doses for advanced disease (T3). Nodal control was improved with increasing radiation doses for nodes less than or equal to3 cm as well as for nodes >3 cm. The incidence of fatal radiation complication was 2.5%.

• OSTI ID: 6514333
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 8:8; ISSN IOBPD
• Country of Publication: United States
• Language: English

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