T2 glottic cancer: an analysis of dose-time-volume factors

Journal Article · Sun Nov 01 04:00:00 EST 1981 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(81)90078-X· OSTI ID:5798326

Harwood, A R; Beale, F A; Cummings, B J; Keane, T J; Rider, W D

Two hundred and forty-four patients with T2NOMO glottic cancer seen at the Princess Margaret Hospital between 1965 and 1977 are analyzed with respect to the influence of dose-time-volume factors on control of this stage of disease by radiotherapy. Sixty-seven percent of the patients are alive and well five years following treatment; 16% died as a result of glottic cancer and 17% died from intercurrent disease in the five years following treatment. The local control rate by radiotherapy was 72% at three years and 69% at five years. The local control rate by radiotherapy was 80% at five years with a mobile vocal cord and 52% at five years when the cord mobility was impaired (P-0.0005). An increase in field size from less than 36 cm/sup 2/ to greater than 36 cm/sup 2/ resulted in an improvement in local control by radiotherapy from 57-70%. This improvement was confined to the normal mobility group (62% local control versus 83%). Local control was 53% for the overall for the overall group when a nominal standard dose (NSD) of less than 1650 ret was used compared to 81% in the 1650-1699 ret group (P-<0.05). This improved local control versus increasing NDS occurred in both the normal mobility and impaired mobility subgroups of patients in this stage of glottic cancer. On the basis of the data presented, a dose cure curve for T2 glottic cancer was derived and compared to previously obtained dose cure curves for T1 and T3 glottic cancer and the dose complication curve for the larynx. The optimal dose-time-volume factors for T2 glottic cancer are discussed.

• Research Organization: Princess Margaret Hospital, Toronto, Ontario, Canada
• OSTI ID: 5798326
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 7:11; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
BODY
DIGESTIVE SYSTEM
DISEASES
DOSES
LARYNX
MEDICINE
MORTALITY
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATIENTS
PHARYNX
RADIATION DOSES
RADIOLOGY
RADIOTHERAPY
RESPIRATORY SYSTEM
THERAPY
TIME DEPENDENCE