Significance of bone-marrow scintigraphy in aplastic anemia: concise communication. [/sup 99m/Tc-sulfur colloid; /sup 111/In-transferrin]
Tc-99m colloid and In-111 transferrin were used in a semiquantitative scintigraphic study of bone-marrow activity in 76 patients with aplastic anemia, the majority of which were severe cases. The results are compared with other known prognostic parameters and with a predictive index formulated from a prior multiparametric analysis performed in 352 cases. In 47 cases parallel abnormality of Tc and In uptakes was noted and was well correlated with other prognostic factors. Indium uptake is apparently a good indicator of the severity of aplasia; extension of active erythroid tissue, demonstrated with this method, is correlated with prognosis. In nine cases, excessive in uptake is explained by dyserythropoiesis associated with granulo- and thrombocytopenia (Fanconi's anemia in most cases). In 20 of our patients, TcSC uptake was excessive compared with that of In and with other prognostic factors. Statistically, this phenomenon carries an unfavorable prognosis but its physiological meaning remains to be defined.
- Research Organization:
- Univ. Paris VII, France
- OSTI ID:
- 5568215
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 21:3
- Country of Publication:
- United States
- Language:
- English
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DIAGNOSIS
BONE MARROW
SCINTISCANNING
INDIUM 111
TECHNETIUM 99
ISOMERIC NUCLEI
PATIENTS
RADIOCOLLOIDS
RADIOPHARMACEUTICALS
SULFUR COMPLEXES
TRANSFERRIN
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
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DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
DISPERSIONS
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
GLOBULINS
GLOBULINS-BETA
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
HOURS LIVING RADIOISOTOPES
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PROTEINS
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RADIOISOTOPE SCANNING
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SYMPTOMS
TECHNETIUM ISOTOPES
TISSUES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics