Bone-marrow imaging with indium-111 chloride in aplastic anemia and myelofibrosis: concise communication

Journal Article · Mon Feb 01 04:00:00 EST 1982 · J. Nucl. Med.; (United States)

OSTI ID:5405169

Sayle, B A; Helmer, R E; Birdsong, B A; Balachandran, S; Gardner, F H

Twenty-nine patients with aplastic anemia and 11 patients with myelofibrosis were evaluated with indium-111 chloride bone-marrow imaging, ferrokinetics, and bone-marrow core biopsies. There was good correlation between the erythrocyte cellularity of the marrow and the In-111 bone-marrow scan grades in most patients. In some, the overall scan grade tended to underestimate the erythroid elements because the core biopsy had been taken from the area of the greatest radionuclide concentration on the scan. In patients with aplastic anemia, there was good correlation between the plasma iron clearance t1/2 and the scan grade. Less agreement was found in the comparison between the Fe-59 sacral and organ counts and the red-cell iron utilization. In patients with myelofibrosis, there was poor correlation between the surface counts over the sacrum and the red-cell iron utilization. Plasma iron clearances were abnormally short and were unrelated to the transferrin saturation levels. Eighteen patients were studied several times to evaluate their responses to steroid therapy. In all, there was good correlation between the bone-marrow imaging, the erythrocyte cellularity, ferrokinetics, and the patient's response to therapy. Indium-111 bone-marrow imaging is useful both in evaluating marrow erythroid activity and in following the response to therapy in patients with these diseases.

• Research Organization: University of Texas Medical Branch, Galveston
• OSTI ID: 5405169
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 23:2; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANEMIAS
ANIMAL TISSUES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD-PLASMA CLEARANCE
BODY
BODY FLUIDS
BONE MARROW
CHLORIDES
CHLORINE COMPOUNDS
CLEARANCE
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
ERYTHROCYTES
EVEN-ODD NUCLEI
FIBROSIS
GLOBULINS
GLOBULINS-BETA
HALIDES
HALOGEN COMPOUNDS
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
INDIUM 111
INDIUM CHLORIDES
INDIUM COMPOUNDS
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
IRON 59
IRON ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MATERIALS
METALLOPROTEINS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PATIENTS
PROTEINS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
SYMPTOMS
TISSUES
TRANSFERRIN