Diagnostic value of bone marrow imaging with /sup 111/indium-transferrin and /sup 99m/technetium-colloids in myelofibrosis
Journal Article
·
· Am. J. Hematol.; (United States)
/sup 111/Indium--transferrin (/sup 111/In) and /sup 99m/Technetium-colloids (/sup 99m/Tc) bone marrow imaging of 55 myelofibrosis (MF) cases has been compared with clinical, histological, and iron-kinetics data. The best correlations are seen between the splenic uptake of /sup 111/In with the spleen/sacrum ratio of /sup 59/Fe at the first hour and also with the splenic erythropoiesis histologically assessed in ten splenectomized patients. Moreover, sacrum uptake of /sup 111/In, when compared with sacrum uptake of /sup 59/Fe and with hematopoietic cellularity of the bone marrow reflects faithfully the hematopoietic cell content of the marrow. Thus, /sup 111/In bone marrow imaging provides a noninvasive and useful tool for the diagnosis of myeloid metaplasia in MF. Ferrokinetic studies still appreciate with better insight the amount of ineffective erythropoiesis or hemolysis and remain therefore of great value when splenectomy is discussed.
- Research Organization:
- Hopital Saint-Louis, Paris, France
- OSTI ID:
- 5779088
- Journal Information:
- Am. J. Hematol.; (United States), Journal Name: Am. J. Hematol.; (United States) Vol. 18:3; ISSN AJHED
- Country of Publication:
- United States
- Language:
- English
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OSTI ID:4118558
Related Subjects
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL TISSUES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FORMATION
BODY
BONE MARROW
COLLOIDS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DISEASES
DISPERSIONS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
GLOBULINS
GLOBULINS-BETA
HEMATOPOIETIC SYSTEM
HOURS LIVING RADIOISOTOPES
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
IRON 59
IRON ISOTOPES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
METALLOPROTEINS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PROTEINS
RADIOCOLLOIDS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SKELETAL DISEASES
TECHNETIUM 99
TECHNETIUM ISOTOPES
TISSUES
TRANSFERRIN
YEARS LIVING RADIOISOTOPES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL TISSUES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FORMATION
BODY
BONE MARROW
COLLOIDS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DISEASES
DISPERSIONS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
GLOBULINS
GLOBULINS-BETA
HEMATOPOIETIC SYSTEM
HOURS LIVING RADIOISOTOPES
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
IRON 59
IRON ISOTOPES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
METALLOPROTEINS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PROTEINS
RADIOCOLLOIDS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SKELETAL DISEASES
TECHNETIUM 99
TECHNETIUM ISOTOPES
TISSUES
TRANSFERRIN
YEARS LIVING RADIOISOTOPES