Neurotransmitter mechanisms of the action of the antihistamine dimebon on the brain

Journal Article · Sat Nov 01 04:00:00 EST 1986 · Bull. Exp. Biol. Med. (Engl. Transl.); (United States)

DOI:https://doi.org/10.1007/BF00839604· OSTI ID:5563318

Shadurskaya, S K; Khomenko, A I; Pereverzev, V A; Balakeevskii, A I

To discover the possible mechanism of the stimulating effect of dimebon on the CNS, the action of the drug was studied on catecholamine concentrations and turnover and activity of forms of monoamine oxidase (MAO), differing in the substrate metabolized, in brain structures involved in the regulation of the emotional state and in the regulation of motor activity in rats. /sup 3/H-serotonin creatinine-sulfate, /sup 3/H-dopamine hydrochloride, and /sup 14/C- benzylamine hydrochloride were used as substrates. The results show that dimebon can inhibit MAO activity in the basal ganglia and other brain structures both in vitro and in vivo, and can cause changes in DA and NA metabolism and in functional activity of catecholaminergic neuronal structures of the brain.

• Research Organization: Minsk Medical Institute, USSR
• OSTI ID: 5563318
• Journal Information: Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Journal Name: Bull. Exp. Biol. Med. (Engl. Transl.); (United States) Vol. 101:6; ISSN BEXBA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
AMINES
ANIMALS
ANTIHISTAMINICS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZAARENES
AZOLES
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BODY
BRAIN
CARDIOTONICS
CARDIOVASCULAR AGENTS
CATECHOLAMINES
CENTRAL NERVOUS SYSTEM
CHEMISTRY
DOPAMINE
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ENZYME ACTIVITY
ENZYME INHIBITORS
ENZYMES
HETEROCYCLIC COMPOUNDS
HISTAMINE
HYDROXY COMPOUNDS
IMIDAZOLES
INDOLES
INHIBITION
LABELLED COMPOUNDS
LABELLING
MAMMALS
MEMBRANE PROTEINS
METABOLISM
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDOREDUCTASES
PHENOLS
POLYPHENOLS
PROTEINS
PYRROLES
RADIOENZYMATIC ASSAY
RADIOPROTECTIVE SUBSTANCES
RATS
RECEPTORS
RODENTS
SEROTONIN
SUBSTRATES
SYMPATHOMIMETICS
TRITIUM COMPOUNDS
TRYPTAMINES
VERTEBRATES