Genotoxic properties of haloacetonitriles: drinking water by-products of chlorine disinfection

Journal Article · Tue Apr 01 04:00:00 EST 1986 · Fundam. Appl. Toxicol.; (United States)

DOI:https://doi.org/10.1016/0272-0590(86)90218-6· OSTI ID:5558870

Daniel, F B; Schenck, K M; Mattox, J K; Lin, E L; Haas, D L; Pereira, M A

Chlorinated and brominated haloacetonitriles (HAN), known drinking water contaminants which form during chlorine disinfection, were investigated for genotoxic activity. The HAN produced DNA strand breaks in cultured human lymphoblastic (CCRF-CEM) cells, bound to the nucleophilic trapping agent 4-(p-nitrobenzyl)pyridine and formed a covalent bond to polyadenylic acid in a cell-free reaction system. Thus, we have demonstrated that these chemicals are genotoxic, which would indicate a potential for carcinogenic activity and for human health hazard.

• Research Organization: Environmental Protection Agency, Cincinnati, OH
• OSTI ID: 5558870
• Journal Information: Fundam. Appl. Toxicol.; (United States), Journal Name: Fundam. Appl. Toxicol.; (United States) Vol. 3; ISSN FAATD
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATION
ANIMAL CELLS
AZINES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
BROMINE
CELL CULTURES
CHEMICAL REACTIONS
CHLORINATION
CHLORINE
CONNECTIVE TISSUE CELLS
CONTAMINATION
COVALENCE
DNA
DRINKING WATER
ELEMENTS
GENETIC EFFECTS
HALOGENATION
HALOGENS
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
LEUKOCYTES
LYMPHOCYTES
MATERIALS
MUTAGENS
NITRILES
NONMETALS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXYGEN COMPOUNDS
POLLUTION
PYRIDINES
SOMATIC CELLS
STRAND BREAKS
TOXICITY
WATER
WATER POLLUTION