Non-Hodgkin's lymphomas of head and neck extranodal sites
Journal Article
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
The initial staging, therapy and course of 156 patients with non-Hodgkin's lymphomas of head and neck extranodal sites were analyzed to determine whether they have a natural history which differs from primary nodal disease. The sites involved were: Waldeyer's ring - 103 patients (tonsil - 60, nasopharynx - 25, base of tongue -18), and extralymphatic sites - 53 patients (salivary gland - 20, paranasal sinus - 20, oral cavity - 10, and larynx - 3). Seventy-six percent had unfavorable histologies and 24% had favorable histologies. Fifty-three percent had pathologic Stages I-II and 47% had Stages III-IV. The 5-year survival was influenced by primary sites. The 5-year survival was also influenced by histology: unfavorable histologies - 39%, favorable histologies - 69%. The Ann Arbor staging system was more useful than TNM for determining outcome. For patients with Stage I-II unfavorable histologies treated with radiation alone, the 5-year surival was: involved field - 24%, extended field - 42%, total lymphoid irradiation - 52%. The majority of patients who failed did so in extranodal sites. Forty-one patients with advanced disease received a variety of chemotherapy regimens as the sole treatment. For head and neck extranodal lymphomas, limited radiation is inadequate, and combined modality programs should be considered.
- Research Organization:
- Stanford Univ. School of Medicine, CA
- OSTI ID:
- 5555670
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 11:2; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ACCELERATORS
BODY
BODY AREAS
CHEMOTHERAPY
DIGESTIVE SYSTEM
DISEASES
ENERGY RANGE
EVALUATION
EXTERNAL IRRADIATION
GLANDS
HEAD
IRRADIATION
LINEAR ACCELERATORS
LYMPH NODES
LYMPHATIC SYSTEM
LYMPHOMAS
MEDICINE
MEV RANGE
MEV RANGE 01-10
NECK
NEOPLASMS
NUCLEAR MEDICINE
ORAL CAVITY
ORGANS
PARTIAL BODY IRRADIATION
PATIENTS
PHARYNX
RADIOLOGY
RADIOTHERAPY
RESPIRATORY SYSTEM
SALIVARY GLANDS
THERAPY
62 RADIOLOGY AND NUCLEAR MEDICINE
ACCELERATORS
BODY
BODY AREAS
CHEMOTHERAPY
DIGESTIVE SYSTEM
DISEASES
ENERGY RANGE
EVALUATION
EXTERNAL IRRADIATION
GLANDS
HEAD
IRRADIATION
LINEAR ACCELERATORS
LYMPH NODES
LYMPHATIC SYSTEM
LYMPHOMAS
MEDICINE
MEV RANGE
MEV RANGE 01-10
NECK
NEOPLASMS
NUCLEAR MEDICINE
ORAL CAVITY
ORGANS
PARTIAL BODY IRRADIATION
PATIENTS
PHARYNX
RADIOLOGY
RADIOTHERAPY
RESPIRATORY SYSTEM
SALIVARY GLANDS
THERAPY