Inhalation developmental toxicology studies: Teratology study of 1,3-butadiene in mice: Final report

Technical Report · Sun Nov 01 04:00:00 EST 1987

DOI:https://doi.org/10.2172/5555439· OSTI ID:5555439

Hackett, P L; Sikov, M R; Mast, T J; Brown, M G; Buschbom, R L; Clark, M L; Decker, J R; Evanoff, J J; Rommereim, R L; Rowe, S E; Westerberg, R B

Maternal toxicity, reproductive performance and developmental toxicology were evaluated in CD-1 mice following whole-body, inhalation exposures to 0, 40, 200 and 1000 ppM of 1,3-butadiene. The female mice, which had mated with unexposed males were exposed to the chemical for 6 hours/day on 6 through 15 dg and sacrificed on 18 dg. Maternal animals were weighed prior to mating and on 0, 6, 11 and 18 dg; the mice were observed for mortality, morbidity and signs of toxicity during exposure and examined for gross tissue abnormalities at necropsy. Live fetuses were weighed and subjected to external, visceral and skeletal examinations to detect growth retardation and morphologic anomalies. Significant concentration-related decreases were detected in a number of maternal body weight measures. There was a significant concentration-related depression of fetal body weights and placental weights. Body weights of male fetuses of all exposed groups were significantly lower than values for control fetuses; weights of female fetuses were significantly depressed in the mice exposed to 200 and 1000 ppM. In the 200- and 1000-ppM exposure groups, weights of placentas of male fetuses were significantly decreased, but placental weights of female fetuses were significantly affected only in litters exposed to the highest 1,3-butadiene concentration. This exposure regimen produced significant signs of maternal toxicity at concentrations of 200 and 1000 ppM 1,3-butadiene.

• Research Organization: Pacific Northwest Lab., Richland, WA (USA)
• DOE Contract Number: AC06-76RL01830
• OSTI ID: 5555439
• Report Number(s): PNL-6412; ON: DE88004187
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BUTADIENE
CHRONIC EXPOSURE
COMPARATIVE EVALUATIONS
DIENES
DOCUMENT TYPES
DOSE-RESPONSE RELATIONSHIPS
FEMALES
HYDROCARBONS
INHALATION
INTAKE
LIFE SPAN
LITTER SIZE
MORTALITY
ORGANIC COMPOUNDS
POLYENES
PRENATAL EXPOSURE
PROGRESS REPORT
TERATOGENESIS
TOXICITY