Dominant lethal study in CD-1 mice following inhalation exposure to 1,3-butadiene: Final technical report

Technical Report · Fri Apr 01 04:00:00 EST 1988

DOI:https://doi.org/10.2172/5129962· OSTI ID:5129962

Hackett, P L; Mast, T J; Brown, M G; Clark, M L; Evanoff, J J; Rowe, S E; McClanahan, B J; Buschbom, R L; Decker, J R; Rommereim, R L; Westerberg, R B

The effects of whole-body inhalation exposures to 1,3-butadiene on the reproductive system was evaluated. The results of dominant lethality in CD-1 male mice that were exposed to 1,3-butadiene are described. Subsequent to exposure, males were mated with two unexposed females. Mating was continued for 8 weeks with replacement of two females each week. Gravid uteri were removed, and the total number, position and status of implantations were determined. The mice were weighed prior to exposure and at 0, 1, 2, 3, 4, 5, 6, 7, and 8 weeks after exposure and at sacrifice. The animals were observed for mortality, morbidity and signs of toxicity throughout the study. 19 refs., 5 figs., 9 tabs.

• Research Organization: Pacific Northwest Lab., Richland, WA (USA)
• DOE Contract Number: AC06-76RL01830
• OSTI ID: 5129962
• Report Number(s): PNL-6545; ON: DE88010185
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKENES
ANIMALS
BIOLOGICAL EFFECTS
BUTENES
DOCUMENT TYPES
DOMINANT MUTATIONS
GENETIC EFFECTS
HYDROCARBONS
INHALATION
INTAKE
LETHAL MUTATIONS
MALES
MAMMALS
MICE
MUTATIONS
ORGANIC COMPOUNDS
PROGRESS REPORT
REPRODUCTION
RODENTS
VERTEBRATES