Inhalation developmental toxicology studies of 1,3-butadiene in the rat: Final report

Technical Report · Sun Nov 01 04:00:00 EST 1987

DOI:https://doi.org/10.2172/5664174· OSTI ID:5664174

Hackett, P. L.; Sikov, M. R.; Mast, T. J.; Brown, M. G.; Buschbom, R. L.; Clark, M. L.; Decker, J. R.; Evanoff, J. J.; Rommereim, R. L.; Rowe, S. E.; Westerberg, R. B.

Maternal toxicity, reproductive performance and developmental toxicology were evaluated in Sprague-Dawley-derived rats during and following 6 hours/day, whole-body, inhalation exposures to 0, 40, 200, and 1000 ppM of 1,3-butadiene. The female rats (Ns = 24 to 28), which had mated with unexposed males, were exposed to the chemical from 6 through 15 dg and sacrificed on 20 dg. Maternal animals were weighed prior to mating and on 0, 6, 11, 16 and 20 dg; the rats were observed for mortality, morbidity and signs of toxicity during exposure and examined for gross tissue abnormalities at necropsy. Live fetuses were weighed and subjected to external, visceral and skeletal examinations to detect growth retardation and morphologic anomalies. There were no significant differences among treatment groups in maternal body weights or extragestational weights of rats exposed to 1,3-butadiene concentrations of 40 or 200 ppM, but, in animals exposed to 1000 ppM, significantly depressed body weight gains were observed during the first 5 days of exposure and extragestational weight gains tended to be lower than control values. These results, and the absence of clinical signs of toxicity, were considered to indicate that there was no maternal toxicity at exposure levels of 200 ppM or lower. The percentage of pregnant animals and the number of litters with live fetuses were unaffected by treatment. Under the conditions of this exposure regimen, there was no evidence for a teratogenic response to 1,3-butadiene exposure.

• Research Organization: Pacific Northwest Lab., Richland, WA (USA)
• DOE Contract Number: AC06-76RL01830
• OSTI ID: 5664174
• Report Number(s): PNL-6414; ON: DE88004186
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BUTADIENE
CHRONIC EXPOSURE
COMPARATIVE EVALUATIONS
DIENES
DOSE-RESPONSE RELATIONSHIPS
FEMALES
HYDROCARBONS
INHALATION
INTAKE
LIFE SPAN
LITTER SIZE
MAMMALS
MORTALITY
ORGANIC COMPOUNDS
POLYENES
PRENATAL EXPOSURE
RATS
RODENTS
TERATOGENESIS
TOXICITY
VERTEBRATES