Effect of dietary vanadium on fatty acid and cholesterol synthesis and turnover in the chick
Day-old, male, broiler type chicks were used to study the effect of 100 ppm dietary vanadium on fatty acid and cholesterol synthesis and turnover in vivo. After feeding the experimental diets for 4 weeks body weight and liver weight of chicks fed 100 ppm vanadium were significantly less than those of the control chicks and liver total lipid and cholesterol tended to be slightly higher than the levels of the control chicks. The rate of incorporation of (1-/sup 14/C)acetate into plasma and liver total lipid, cholesterol and fatty acid was higher in chicks fed vanadium than the control group at any of the time being tested after the injection. There was a significant increase in the hepatic citrate cleavage enzyme activity among chicks fed 100 ppm vanadium, whereas, there was no significant change in acetate thiokinase activity. Turnover rate of plasma total lipid and fatty acid in vanadium fed chicks was lower than the control. The turnover rate of plasma cholesterol determined by administering (4-/sup 14/C)cholesterol and periodically measuring the specific activity of plasma cholesterol was higher in chicks fed vanadium than in those fed the basal diet. 31 references, 1 figure, 9 tables.
- Research Organization:
- Univ. of California, Davis
- OSTI ID:
- 5551757
- Journal Information:
- J. Nutr.; (United States), Vol. 106:2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CARBOXYLIC ACIDS
BIOSYNTHESIS
METABOLISM
CHOLESTEROL
VANADIUM
BIOLOGICAL EFFECTS
ANIMAL GROWTH
BLOOD CHEMISTRY
CHICKENS
INGESTION
ANIMALS
BIRDS
ELEMENTS
FOWL
GROWTH
HYDROXY COMPOUNDS
INTAKE
METALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
STEROIDS
STEROLS
SYNTHESIS
TRANSITION ELEMENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)