Interaction of dietary mercury and biotin-deficiency on hepatic lipogenesis in chicks
Journal Article
·
· Poult. Sci.; (United States)
OSTI ID:6300619
Broilers were fed control or biotin-deficient diets based upon glucose and casein starting at day-old. At 7 days, one-half the chicks fed the biotin-deficient diet were administered 200 ppm Hg (as HgCl/sub 2/) continuously in the drinking water, while the remaining biotin-deficient chicks and the control chicks continued to receive tap water. At 4 weeks, hepatic fatty acid synthetse (FAS) and acetyl-CoA carboxylase (ACC) activities and in vivo lipogenesis from /sup 14/C-acetate were measured in randomly selected chicks from each of the 3 treatments. Specific activity of FAS was stimulated slightly by biotin-deficiency but Hg reduced activity to control values in deficient chicks. Specific activity of ACC was reduced to one-half of control values by biotin deficiency and Hg had no further effect. Incorporation of /sup 14/C-acetate into hepatic fatty acids was reduced markedly by biotin-deficiency but Hg returned incorporation to control values in deficient chicks. ACC is presumably the rate-limiting enzyme for lipogenesis. Therefore, the data suggest that Hg somehow stimulates the in vivo activity of this enzyme in biotin-deficient chicks.
- Research Organization:
- North Carolina State Univ., Raleigh
- OSTI ID:
- 6300619
- Journal Information:
- Poult. Sci.; (United States), Journal Name: Poult. Sci.; (United States) Vol. 56:5; ISSN POSCA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOSYNTHESIS
BIRDS
CARBON 14
CARBON ISOTOPES
CHICKENS
ELEMENTS
ENZYMES
EVEN-EVEN NUCLEI
FOWL
ISOTOPES
LIGHT NUCLEI
MERCURY
METABOLIC ACTIVATION
METABOLISM
METALS
NUCLEI
RADIOISOTOPES
STIMULATION
SYNTHESIS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOSYNTHESIS
BIRDS
CARBON 14
CARBON ISOTOPES
CHICKENS
ELEMENTS
ENZYMES
EVEN-EVEN NUCLEI
FOWL
ISOTOPES
LIGHT NUCLEI
MERCURY
METABOLIC ACTIVATION
METABOLISM
METALS
NUCLEI
RADIOISOTOPES
STIMULATION
SYNTHESIS
VERTEBRATES
YEARS LIVING RADIOISOTOPES