Brain nuclear magnetic resonance imaging enhanced by a paramagnetic nitroxide contrast agent: preliminary report. [Dogs]

Journal Article · Tue Nov 01 00:00:00 EST 1983 · AJR, Am. J. Roentgenol.; (United States)

DOI:https://doi.org/10.2214/ajr.141.5.1019· OSTI ID:5551387

Brasch, R C ^[1]; Nitecki, D E; Brant-Zawadzki, M; Enzmann, D R; Wesbey, G E; Tozer, T N; Tuck, L D; Cann, C E; Fike, J R; Sheldon, P

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1. Univ. of California, San Francisco

Contrast-enhancing agents for demonstrating abnormalities of the blood-brain barrier may extend the diagnostic utility of proton nuclear magnetic resonance (NMR) imaging. TES, a nitroxide stable free radical derivative, was tested as a central nervous system contrast enhancer in dogs with experimentally induced unilateral cerebritis or radiation cerebral damage. After intravenous injection of TES, the normal brain showed no change in NMR appearance, but areas of disease demonstrated a dramatic increase (up to 45%) in spin-echo intensity and a decrease in T/sub 1/, relaxation times. The areas of disease defined by TES enhancement were either not evident on the nonenhanced NMR images or were better defined after contrast administration. In-depth tests of toxicity, stability, and metabolism of this promising NMR contrast agent are now in progress.

• OSTI ID: 5551387
• Journal Information: AJR, Am. J. Roentgenol.; (United States), Vol. 141:5
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BRAIN
DIAGNOSTIC USES
NUCLEAR MAGNETIC RESONANCE
CONTRAST MEDIA
EVALUATION
BLOOD-BRAIN BARRIER
DOGS
NITRO COMPOUNDS
RELAXATION TIME
ANIMALS
BODY
CENTRAL NERVOUS SYSTEM
MAGNETIC RESONANCE
MAMMALS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RESONANCE
USES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics