Work in progress: nuclear magnetic resonance study of a paramagnetic nitroxide contrast agent for enhancement of renal structures in experimental animals

Journal Article · Wed Jun 01 04:00:00 EDT 1983 · Radiology; (United States)

DOI:https://doi.org/10.1148/radiology.147.3.6844613· OSTI ID:5298966

Brasch, R C; London, D A; Wesbey, G E; Tozer, T N; Nitecki, D E; Williams, R D; Doemeny, J; Tuck, L D; Lallemand, D P

A piperidinyl nitroxide stable free radical derivative, TES, was tested as an NMR contrast enhancer of renal structures in normal animals and animals with experimentally induced unilateral renal ischemia, renal vascular congestion, and hydronephrosis. Physiologic measurements indicated that TES is rapidly excreted in the urine with a clearance rate equal to the glomerular filtration rate. Because the compound is strongly paramagnetic, it increases the observable NMR intensity within the kidneys and urine in relatively low doses (0.04 to 0.9 g/kg). TES-enhanced spin echo renal images clearly demonstrated the presence of disease and functional abnormalities in diseased kidneys. These abnormalities were either not evident or only indirectly suggested on nonenhanced NMR images.

• Research Organization: Univ. of California, San Francisco
• OSTI ID: 5298966
• Journal Information: Radiology; (United States), Journal Name: Radiology; (United States) Vol. 147:3; ISSN RADLA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINES
ANIMALS
AZINES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
CARDIOVASCULAR DISEASES
CHALCOGENIDES
CLEARANCE
CONTRAST MEDIA
DISEASES
EVALUATION
EXCRETION
HETEROCYCLIC COMPOUNDS
IMAGES
ISCHEMIA
KIDNEYS
MAGNETIC RESONANCE
MATERIALS
NITROGEN COMPOUNDS
NITROGEN OXIDES
NUCLEAR MAGNETIC RESONANCE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
PIPERIDINES
PYRIDINES
RENAL CLEARANCE
RESONANCE
SPIN ECHO
URINE
VASCULAR DISEASES
WASTES