Influence of dietary methionine on the metabolism of selenomethionine in rats
- Oregon State Univ., Corvallis (USA)
To determine the influence of methionine on selenomethionine (SeMet) metabolism, weanling male rats were fed for 8 wk a basal diet marginally deficient in sulfur amino acids, containing 2.0 micrograms selenium (Se)/g as DL-SeMet and supplemented with 0, 0.3, 0.6 or 1.2% DL-methionine. Increased dietary methionine caused decreased selenium deposition in all tissues examined but increased glutathione peroxidase activity in testes, liver and lungs. A positive correlation was found between dietary methionine and the calculated percentage of selenium associated with GSHPx. In a second experiment, {sup 75}SeMet was injected into weanling male rats which had been fed the basal diet containing 2.0 micrograms selenium as DL-SeMet with or without the addition of 1.0% methionine. The selenoamino acid content of tissues and the distribution of {sup 75}Se in erythrocyte proteins were determined. In comparison to the rats fed the basal diet without added methionine, significantly more {sup 75}Se-selenocysteine was found in liver and muscle, more {sup 75}Se was found in erythrocyte GSHPx and less {sup 75}Se was found in erythrocyte hemoglobin of rats fed 1.0% methionine. These data suggest that methionine diverts SeMet from incorporation into general proteins and enhances its conversion to selenocysteine for specific selenium-requiring proteins, such as GSHPx.
- OSTI ID:
- 5546504
- Journal Information:
- Journal of Nutrition; (USA), Journal Name: Journal of Nutrition; (USA) Vol. 119:7; ISSN 0022-3166; ISSN JONUA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
CARBOXYLIC ACIDS
DAYS LIVING RADIOISOTOPES
DIET
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
ENZYME ACTIVITY
ENZYMES
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LIPOTROPIC FACTORS
MAMMALS
METABOLISM
METHIONINE
NUCLEI
ORAL ADMINISTRATION
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANOMETALLIC COMPOUNDS
OXIDOREDUCTASES
PEROXIDASES
RADIOISOTOPES
RATS
RODENTS
SELENIUM
SELENIUM 75
SELENIUM ISOTOPES
SEMIMETALS
TISSUE DISTRIBUTION
TRACER TECHNIQUES
VERTEBRATES
WEIGHT