Relative effectiveness of {sup 239}Pu and some other internal emitters for bone cancer induction in beagles

Journal Article · Sat Oct 01 04:00:00 EDT 1994 · Health Physics

DOI:https://doi.org/10.1097/00004032-199403000-00017· OSTI ID:55319

Lloyd, R D; Miller, S C; Taylor, G N; Bruenger, F W; Jee, W S.S.; Angus, W ^[1]

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1. Univ. of Utah, Salt Lake City, UT (United States)

The toxicity ratio (relative effectiveness per gray of average skeletal dose) has been estimated for bone cancer induction in beagles injected as young adults with a number of bone-seeking internal emitters. These experiments yielded calculated toxicity ratios ({+-} SD) relative to {sup 226}Ra = 1.0 of {sup 239}Pu = 16 {+-} 5 (single exposure to monomeric Pu) and 32 {+-} 10 (continuous exposure from an extraskeletal deposit in the body), {sup 224}Ra = 16 {+-} 5 (chronic exposure) and approximately 6 {+-} 2 (single exposure), {sup 228}Th = 8.5 {+-} 2.3, {sup 241}Am = 6 {+-} 0.8, {sup 228}Ra = 2.0 {+-} 0.5, {sup 249}Cf = 6 {+-} 3, {sup 252}Cf = 4 {+-}2, {sup 90}Sr = 1.0 {+-} 0.5 (for high doses) and 0.05 {+-} 0.03 (for low doses) and 0.01 {+-} 0.01 (for extremely low doses). Because no skeletal malignancies were observed among beagles given only {sup 253}Es, the toxicity ratio is undefined. 43 refs., 2 tabs.

• Sponsoring Organization: USDOE
• DOE Contract Number: AC04-76EV01013
• OSTI ID: 55319
• Journal Information: Health Physics, Journal Name: Health Physics Journal Issue: 4 Vol. 67; ISSN HLTPAO; ISSN 0017-9078
• Country of Publication: United States
• Language: English

Related Subjects

56 BIOLOGY AND MEDICINE
APPLIED STUDIES
AMERICIUM 241
BEAGLES
BIOLOGICAL RADIATION EFFECTS
BONE TISSUES
CALIFORNIUM 249
CALIFORNIUM 252
EINSTEINIUM 253
NEOPLASMS
PLUTONIUM 239
RADIUM 224
RADIUM 228
RBE
STRONTIUM 90
THORIUM 228