Stimulation of 25-hydroxyvitamin D/sub 3/-1. cap alpha. -hydroxylase by phosphate depletion

Journal Article · Thu Jan 01 04:00:00 EST 1976 · J. Biol. Chem.; (United States)

OSTI ID:5525975

Baxter, L A; DeLuca, H F

The ability of low phosphorus diets to stimulate the activity of the 25-hydroxyvitamin D/sub 3/-1..cap alpha..-hydroxylase was tested in the chick. Feeding low phosphorus diets for 2 weeks resulted in a marked increase in enzyme activity relative to chicks fed a normal phosphorus diet. Stimulation of the 25-hydroxyvitamin D/sub 3/-1..cap alpha..-hydroxylase activity by low phosphorus diets, however, was not as great as that observed with a low calcium diet. The low phosphorus and low calcium diets also resulted in a marked stimulation of intestinal calcium absorption. The stimulation by low calcium diets probably results from increased 1,25-dihydroxyvitamin D/sub 3/ synthesis, whereas the stimulation by phosphate deprivation is only partly the result of increased 1,25-dihydroxyvitamin D/sub 3/ production.

• Research Organization: Univ. of Wisconsin, Madison
• OSTI ID: 5525975
• Journal Information: J. Biol. Chem.; (United States), Journal Name: J. Biol. Chem.; (United States) Vol. 251:10; ISSN JBCHA
• Country of Publication: United States
• Language: English

Related Subjects

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551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALKALINE EARTH METALS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIRDS
CALCIUM
CHICKENS
CHOLECALCIFEROL
DIET
ELEMENTS
FOWL
HYDROGEN ISOTOPES
HYDROXYLATION
INTESTINAL ABSORPTION
ISOTOPES
LIGHT NUCLEI
METALS
NONMETALS
NUCLEI
ODD-EVEN NUCLEI
PHOSPHORUS
RADIOISOTOPES
STIMULATION
TRITIUM
UPTAKE
VERTEBRATES
VITAMIN D
VITAMINS
YEARS LIVING RADIOISOTOPES