Production of tungsten-188 and osmium-194 in a nuclear reactor for new clinical generators
Rhenium-188 and iridium-194 are potential candidates for radioimmunotherapy with monoclonal antibodies directed against tumor-associated antigens. Both nuclei are short-lived and decay by high energy {Beta}{minus} emission. In addition, both nuclei emit {gamma}-rays with energy suitable for imaging. An important characteristics is availability of {sup 188}Re and {sup 194}Ir from decay of reactor-produced parents ({sup 188}W and {sup 194}Os, respectively) in convenient generator systems. The {sup 188}W and {sup 194}Os are produced by double neutron capture of {sup 186}W and {sup 192}Os, respectively. The large scale production yields of {sup 188}W in several nuclear reactors will be presented. We also report a new management for the cross-section of {sup 193}Os(n,{gamma}){sup 194}Os reaction and discuss the feasibility of producing sufficient quantities of {sup 194}Os. 17 refs., 1 fig., 2 tabs.
- Research Organization:
- Oak Ridge National Lab., TN (USA)
- Sponsoring Organization:
- DOE; USDOE, Washington, DC (USA)
- DOE Contract Number:
- AC05-84OR21400
- OSTI ID:
- 5525933
- Report Number(s):
- CONF-910503-27-Extd.Abst.; ON: DE91014544
- Country of Publication:
- United States
- Language:
- English
Similar Records
The {sup 194}Os/{sup 194}Ir generator: Production and purification of {sup 194}Os
Nuclear medicine program progress report for quarter ending March 31, 1991
Related Subjects
070100 -- Physical Isotope Separation
21 SPECIFIC NUCLEAR REACTORS AND ASSOCIATED PLANTS
220600 -- Nuclear Reactor Technology-- Research
Test & Experimental Reactors
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400703 -- Radiochemistry & Nuclear Chemistry-- Radioisotope Production
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BARYONS
BETA DECAY
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY
BETA-MINUS DECAY RADIOISOTOPES
CROSS SECTIONS
DAYS LIVING RADIOISOTOPES
DECAY
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
ENRICHED URANIUM REACTORS
EPITHERMAL NEUTRONS
EPITHERMAL REACTORS
EVEN-EVEN NUCLEI
EVEN-ODD NUCLEI
FAST REACTORS
FERMIONS
FFTF REACTOR
GAMMA RADIATION
HADRONS
HALF-LIFE
HEAVY NUCLEI
HEAVY WATER COOLED REACTORS
HEAVY WATER MODERATED REACTORS
HFBR REACTOR
HFIR REACTOR
HOURS LIVING RADIOISOTOPES
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRIDIUM 194
IRIDIUM ISOTOPES
IRRADIATION REACTORS
ISOMERIC TRANSITION ISOTOPES
ISOTOPE PRODUCTION
ISOTOPE PRODUCTION REACTORS
ISOTOPES
LIQUID METAL COOLED REACTORS
MINUTES LIVING RADIOISOTOPES
MURR REACTOR
NEUTRON FLUX
NEUTRONS
NUCLEAR DECAY
NUCLEI
NUCLEONS
ODD-ODD NUCLEI
OSMIUM 192
OSMIUM 193
OSMIUM 194
OSMIUM ISOTOPES
RADIATION FLUX
RADIATIONS
RADIOISOTOPE GENERATORS
RADIOISOTOPES
REACTORS
RESEARCH AND TEST REACTORS
RESEARCH REACTORS
RHENIUM 188
RHENIUM ISOTOPES
SECONDS LIVING RADIOISOTOPES
SODIUM COOLED REACTORS
STABLE ISOTOPES
TANK TYPE REACTORS
TEST REACTORS
THERMAL NEUTRONS
THERMAL REACTORS
TRAINING REACTORS
TUNGSTEN 186
TUNGSTEN 188
TUNGSTEN ISOTOPES
WATER COOLED REACTORS
WATER MODERATED REACTORS
YEARS LIVING RADIOISOTOPES
YIELDS