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Mutagenicity of Tris(2,3-dibromopropyl) phosphate in mammalian gonad and bone marrow tissue

Journal Article · · J. Natl. Cancer Inst.; (United States)
OSTI ID:5523713
;

The mutagenic and clastogenic (chromosome breaking) effects of the flame retardant Tris(2,3-dibromopropyl) phosphate (Tris-BP) were investigated in two mammalian in vivo assays, the bone marrow micronucleus test and the abnormal sperm head assay. Two potency of Tris-BP was determined in the Salmonella-mammalian microsome assay. Tris-BP was mutagenic in all three assays, in both mammalian tests, nearly toxic doses were required in B6C3F mice for positive mutagenic and clastogenic results. In the micronucleus test, Tris-BP was a weak clastogen, whereas in the abnormal sperm head assay, Tris-BP was observed to be strongly mutagenic. The abnormal sperm head data might imply genetic damage to germ tissue. The data suggested a means for possibly monitoring Tris-BP exposure. Thus besides being a strong mutagen on bacterial systems, Tris-BP was also a weak clastogen as detected in bone marrow cells and was a mutagen to gonad tissue.

OSTI ID:
5523713
Journal Information:
J. Natl. Cancer Inst.; (United States), Journal Name: J. Natl. Cancer Inst.; (United States) Vol. 66:4; ISSN JNCIA
Country of Publication:
United States
Language:
English

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Related Subjects

550300 -- Cytology
550400 -- Genetics
550700 -- Microbiology
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BACTERIA
BIOASSAY
BONE MARROW CELLS
CHEMICAL REACTIONS
CHROMOSOMAL ABERRATIONS
CHROMOSOME BREAKAGE
CHROMOSOMES
COMBUSTION
CONNECTIVE TISSUE CELLS
DOSE-RESPONSE RELATIONSHIPS
FLAMES
GERM CELLS
IN VIVO
INHIBITION
MAMMALS
MICE
MICROORGANISMS
MUTAGENESIS
MUTATIONS
OXIDATION
OXYGEN COMPOUNDS
PHOSPHATES
PHOSPHORUS COMPOUNDS
RODENTS
SALMONELLA
SENSITIVITY
SOMATIC CELLS
THERMOCHEMICAL PROCESSES
TOXICITY
VERTEBRATES