Chemical mutagens: principles and methods for their detection. Vol. 8

Book · Sat Jan 01 04:00:00 EST 1983

OSTI ID:6105271

de Serres, F J

This book describes the detection of genetic damage in mammalian sperm both at specific loci and over the entire genome. The Plenum series is designed to encourage the development and application of testing and monitoring procedures to avert human exposure to mutagenic agents. Topics considered include the detection of effects of mutagens in human populations (e.g., monitoring progeny for evidence of germ-cell mutations, detection of gene mutations in somatic cells), the use of intact cellular activation systems in genetic toxicology assays (e.g., mammalian cell mutagenesis, bacterial mutagenesis), the mouse spot test as a predictor of heritable genetic damage and other endpoints (e.g., relation to measures of heritable mutations, relation to other endpoints), the bone marrow micronucleus assay, the relationships between the chemical structure and mutagenic activity of monocyclic aromatic amines, the measurement of recessive lethal mutations in the mouse, chemically induced changes in sperm in animals and humans, mutational analysis in cultured human-hamster hybrid cells, the genetic toxicology of some known or suspected human carcinogens, and the control of commercial chemicals.

• OSTI ID: 6105271
• Country of Publication: United States
• Language: English

Related Subjects

560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
AROMATICS
BACTERIA
BIOLOGICAL EFFECTS
BODY
BONE MARROW
CARCINOGENS
GAMETES
GENETIC EFFECTS
GENOME MUTATIONS
GERM CELLS
HAMSTERS
HEMATOPOIETIC SYSTEM
HUMAN POPULATIONS
MAMMALS
MICE
MICROORGANISMS
MONITORING
MUTAGEN SCREENING
MUTAGENESIS
MUTAGENS
MUTATIONS
ORGANIC COMPOUNDS
ORGANS
POPULATIONS
PROGENY
RODENTS
SCREENING
SOMATIC CELLS
SPERMATOZOA
STRUCTURAL CHEMICAL ANALYSIS
TECHNOLOGY ASSESSMENT
TISSUES
TOXICITY
VERTEBRATES