Free radicals in biology. Volume III

Book · Sat Jan 01 04:00:00 EST 1977

OSTI ID:5520062

Pryor, W A ^[1]

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1. ed.

This volume covers topics ranging from radiation chemistry to biochemistry, biology, and medicine. This volume attempts to bridge the gap between chemical investigations and the medical applications and implications of free radical reactions. Chapter 1 provides a general introduction to the technique of radiation chemistry, the thermodynamics and kinetic factors that need be considered, the use of pulse radiolysis and flow techniques, and the application of these methods to free radicals of biological interest. Chapter 3 discusses the mechanisms of carbon tetrachloride toxicity. Chapter 4 reviews the morphological, histochemical, biochemical, and chemical nature of lipofuscin pigments. This chapter brings together the evidence that lipofuscin pigments arise from free radical pathology and that the formation of these pigments proves the presence of lipid peroxidation in vivo. Chapter 5 reviews the evidence for production of free (i.e., scavengeable) radicals from the reactions of selected enzymes with their substrates. Chapter 6 discusses one of the systems in which free radical damage is clearly important in vivo, both for man and animal, the damage caused to skin by sunlight. The evidence that free radical reactions can contribute to carcinogenesis dates from the earliest observations that ionizing radiation often produces higher incidences of tumors. A current working hypothesis is that chemical toxins cause damage to DNA and that the repair of this damge may incorporate viral genetic information into the host cell's chromosomes, producing cell transformation and cancer. The mechanism whereby chemical carcinogens become bound to DNA to produce point defects is discussed in Chapter 7.

• OSTI ID: 5520062
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400600 -- Radiation Chemistry
550200* -- Biochemistry
550600 -- Medicine
560151 -- Radiation Effects on Animals-- Man
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOCHEMICAL REACTION KINETICS
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGY
BODY
CARBON TETRACHLORIDE
CARCINOGENESIS
CHEMICAL BONDS
CHEMICAL RADIATION EFFECTS
CHEMICAL REACTIONS
CHEMISTRY
CHLORINATED ALIPHATIC HYDROCARBONS
DECOMPOSITION
DNA
DOCUMENT TYPES
ELECTROMAGNETIC RADIATION
ENZYMES
HALOGENATED ALIPHATIC HYDROCARBONS
KINETICS
LIPIDS
MEDICINE
MORPHOLOGY
NUCLEIC ACIDS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
OXIDATION
PATHOGENESIS
PHOTOCHEMICAL REACTIONS
PIGMENTS
RADIATION CHEMISTRY
RADIATION EFFECTS
RADIATIONS
RADICALS
RADIOLYSIS
REACTION KINETICS
REVIEWS
SKIN
THERMODYNAMICS
TOXICITY
ULTRAVIOLET RADIATION