Free radicals in biology. Volume II

Book · Thu Jan 01 04:00:00 EST 1976

OSTI ID:5501269

Pryor, W A ^[1]

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1. ed.

This volume continues the treatment of topics in free radical biology and free radical pathology from Volume I. In the first chapter, pyridinyl radicals, radicals which are models for those derived from NAD, are discussed. Pyridinyl radicals can be synthesized and isolated and directly studied in a number of chemical systems. The next chapter treats the role of glutathione in the cell. It is becoming even more apparent that this vital thiol controls a large number of important cellular functions. The GSH/GSSG balance has recently been implicated as a control for cellular development; this balance also may be important in relaying the effects of oxidants from one site to another in the body. The next chapter outlines the reactions of singlet oxygen; some of these involve free radicals and some do not. This reactive intermediate appears to be important both in photochemical smog and in cellular chemistry where singlet oxygen is produced by nonphotochemical processes. The production of free radicals from dry tissues, a controversial area with conflicting claims is reviewed. The next chapter outlines the current status of the studies of photochemical smog. The next two chapters treat specific reactive materials which are present in smog. The first discusses the chemistry of nitrogen oxides and ozone. The second chapter treats the chemistry of the peroxyacyl nitrites. These compounds, although present in only small concentration, are among the most toxic components of smog. The last two chapters treat radiation damage to proteins and radiation protection and radical reactions produced by radiation in nucleic acids.

• OSTI ID: 5501269
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
AZINES
BIOLOGICAL EFFECTS
BIOLOGICAL FUNCTIONS
BIOLOGICAL RADIATION EFFECTS
BIOLOGY
CHALCOGENIDES
CHEMICAL RADIATION EFFECTS
CHEMICAL REACTIONS
CHEMISTRY
COENZYMES
DOCUMENT TYPES
DRUGS
ELECTRON SPIN RESONANCE
GLUTATHIONE
GROWTH
HETEROCYCLIC COMPOUNDS
INJURIES
MAGNETIC RESONANCE
NAD
NITRITES
NITROGEN COMPOUNDS
NITROGEN OXIDES
NUCLEIC ACIDS
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
OZONE
PEPTIDES
PHOTOCHEMICAL OXIDANTS
PHOTOCHEMICAL REACTIONS
PLANT CELLS
POLYPEPTIDES
PROTEINS
PYRIDINES
RADIATION CHEMISTRY
RADIATION EFFECTS
RADIATION INJURIES
RADICALS
RADIOPROTECTIVE SUBSTANCES
RESONANCE
RESPONSE MODIFYING FACTORS
REVIEWS
SMOG