Pulmonary antioxidants
One of the most vital of the cellular defenses against pollution is an antioxidant armanentarium which consists of oxidant scavenging molecules such as vitamin E, glutathione, vitamin C, and uric acid as well as a number of enzymes (superoxide dismutase, semidehydroascorbate reductase, catalase, GSH synthetase, GSH peroxidase, GSH reductase, and GSH transferase) and appears to function in keeping oxidant forces under control. Pollutants can upset the oxidant/antioxidant balance of cells by inhibiting vital enzymes, by reacting with oxidant scavengers, or by forming free radical intermediates which initiate uncontrolled tissue reactions with molecular oxygen. The book chapter reviews possible interactions between pollutants and the oxidant/antioxidant balance.
- Research Organization:
- Environmental Protection Agency, Research Triangle Park, NC (USA). Health Effects Research Lab.
- OSTI ID:
- 6272456
- Report Number(s):
- PB-87-188132/XAB; EPA-600/D-87/143
- Country of Publication:
- United States
- Language:
- English
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54 ENVIRONMENTAL SCIENCES
550900 -- Pathology
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59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ANTIOXIDANTS
AROMATICS
ASCORBIC ACID
AZAARENES
BIOLOGICAL EFFECTS
DRUGS
ENZYMES
GLUTATHIONE
HETEROCYCLIC COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PEPTIDES
POLLUTION
POLYPEPTIDES
PROTEINS
PURINES
RADIOPROTECTIVE SUBSTANCES
RESPIRATORY SYSTEM
TOXICITY
URIC ACID
VITAMINS
XANTHINES